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Multiple Sequences Alignment and Structure Prediction of T-cell Surface Glycoprotein CD4 Protein in Various Species

摘要


CD4 protein is present on the surface of 65% of human T cells, it plays an important functional role in the course of human immunodeficiency virus 1(HIV-1) infection. The difference in various CD4 proteins raise the great interest and necessary to investigate. In this project, the sequence diversity and structure difference among 15 species will be focused, and many free tools for biological data analysis, such as MEGAX and PyMOL. The result is that the more similar species evolve, the more similar or even the same length of CD4 will be, and the coverage of CD4 will also become the same.

參考文獻


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Meyerson N R,et al. Identification of owl monkey CD4 receptors broadly compatible with early-stage HIV-1 isolates[J]. Journal of Virology, 2015, 89(16): 8611-8622.
Liu Q, et al. Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Nat Struct Mol Biol. 2017 Apr;24(4):370-378. doi: 10.1038/nsmb.3382.

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