Using two different methods, such as water extraction and alcohol extraction, the antibacterial active component of Artemisia Selengensis polyphenols was extracted. Through MIC value, cell growth curve and other methods, the antibacterial properties of Artemisia Selengensis polyphenols extracts on gingival porphyria and Streptocococcus gingivalis and their impact on the biological membrane of pathogenic bacteria were analyzed, researched. The results showed that Artemisia extract showed certain antibacterial activity on Porphyria gingival Porphyria monas and Streptococcus morphosis, inhibiting acid production and inhibiting its bacterial adhesion.