This article explores Venerable Master Hsing Yun's interpretation of the Four Noble Truths (catvāri āryasatyāni) in early Buddhism, and further correlates the Four Noble Truths to the Four Vast Vows in Mahayana Buddhism, and thereafter, inspect Venerable Master Hsing Yun's ideological direction for Humanistic Buddhism. The research findings indicate that Venerable Master Hsing Yun believes that the Four Noble Truths is one of the most sacred canon, which is proven to provide an authentic way of experiencing life. Moreover, the sermon Buddha delivers in his life time (commonly known as "turning the Wheel of Dharma") can be relates to the later Four Noble Truths and the Four Vast Vows - both have shown ways to end suffering, thereby to let people moving on to a higher levels of existence, and finally to allow Humanistic Buddhism to attain the ideal of uniting mental comprehension and physical practice, and of the past and present.