A sense of relative deprivation is common in Chinese organizational environments. When employees perceive a sense of relative deprivation, it will have a negative impact on their psychology and behavior. Based on social comparison theory and social exchange theory, this study explores the mechanism of action of relative deprivation, and explores the conditions for alleviating the negative effects of relative deprivation. This study selects employees in enterprises as the main research objects, adopts random sampling method, and collects a total of 508 valid questionnaires to explore the impact of relative deprivation on employee engagement through organizational support, with employee vocation orientation as a control variable. Regression analysis shows that: relative deprivation has a positive effect on engagement; organizational support has a mediating effect between relative deprivation and engagement; vocation orientation has a controlling effect.