Bmi-1蛋白在鼻咽癌組織中的表達及意義

Expression and significance of Bmi-1protein in nasopharyngeal carcinoma tissue

古杰鳴(KU Kit Meng)

《鏡湖醫學》 22卷2期 (2022/12) Pp. 5-6+54+i

摘要

目的：觀察Bmi-1蛋白在鼻咽癌（nasopharyngeal carcinoma, NPC）組織中的表達，探討Bmi-1表達與臨床病理特徵的關係。方法：利用免疫組織化學方法檢測103例NPC和80例鼻咽炎症石蠟包埋組織中的Bmi-1表達情況。結果：在103例NPC中，33例Bmi-1呈陰性（32.04%），70例呈陽性（67.96%）。在80例鼻咽炎症中，65例Bmi-1呈陰性（81.25%），15例呈陽性（18.75%），NPC的Bmi-1陽性表達率明顯高於鼻咽炎症（P<0.05）。Bmi-1的陽性率與淋巴結轉移（P=0.01）及臨床TNM分期（P=0.01）密切相關，而與患者性別及年齡無關。結論：研究結果提示Bmi-1參與NPC的發生、發展及侵襲和轉移過程，陽性表達可以作為NPC預後不良的一項指標。

關鍵字

B-細胞特異性莫洛尼鼠白血病毒整合位點1 ； 鼻咽癌 ； 臨床病理特徵

並列摘要

Objective: To investigate the expression of Bmi-1 protein in nasopharyngeal carcinoma (NPC) and explore its associations with clinicopathological features. Methods: 103 NPC and 80 inflammatory nasopharyngeal tissue paraffin embedded samples were collected, and their Bmi-1 expression was detected by immunohistochemistry. Results: Among 103 NPC tissues, thirty-three cases showed Bmi-1 negative (32.04%), and 70 cases were positive (67.96). In 80 nasopharyngeal inflammatory tissues, 65 cases showed Bmi-1 negative (81.25%) and 15 positives (18.75). The Bmi-1 protein expression rate of NPC was significantly higher than that of nasopharyngeal inflammatory tissues (P<0.05). The Bmi-1 protein expression rate of NPC was correlated significantly with lymph node metastasis (P=0.01) and clinical stage (P=0.01), but no significant associations were found with sex and age. Conclusion: The results of this study suggest that Bmi-1 is involved in the occurrence, development, invasion and metastasis of NPC. Bmi-1 positive expression can be used as an indicator of the poor prognosis of NPC.

並列關鍵字

Bmi-1 ； Nasopharyngeal carcinoma ； Clinicopathological features