This study investigates the effects of information uncertainty and information asymmetry on firm operating performance by employing the financial data of American company from 1993 to 2012. The empirical results show that the information uncertainty and information asymmetry effects significantly explain the firm operating performance. In addition, these results are robust when controlling for other well-known firm specific variables. Furthermore, after adding the dummy variable, market competition and financial constraints, the empirical results show that the effects are more significantly.