螢光奈米鑽石、金奈米粒子以及彩色乳膠珠的溫度感測功能

Thermometric Sensing with Fluorescent Nanodiamonds, Gold Nanoparticles and Color Latex Beads

東暉舜(Terumitsu Azuma)

指導教授 ： 王玉麟 ； 張煥正

國立臺灣大學/理學院/物理學研究所/博士(2022年)

https://doi.org/10.6342/NTU202202003

摘要

溫度是熱力學的一個基本屬性。於熱力學，因溫度冷熱差異被應用於各個領域之化學和生物現象演變。在此次論文研究，以螢光奈米鑽石、金奈米顆粒和彩色乳膠珠作為在奈米尺度或微米尺度上測量溫度的靈敏手段。
螢光奈米鑽石作為奈米級溫度感測材料引起了人們的關注，它通過溫度與細胞功能結合到細胞中，進一步的研究了解溫度和細胞之間演變關係。
相較之下，金奈米顆粒和彩色乳膠珠是納入側向流動免疫測定的報告基因。在側流免疫分析的光熱檢測研究中，報告分子被綠色激光加熱，提高了檢測靈敏度。 現在，這種技術已經廣泛的應用於 COVID-19抗原檢測。
本研究將重點關注於使用螢光奈米鑽石、金奈米顆粒和彩色乳膠珠來做實驗並檢測溫度之變遷。

關鍵字

溫度感測 ； 螢光奈米鑽石 ； 橫向流動免疫分析 ； 金奈米顆粒 ； 彩色乳膠珠

並列摘要

Temperature is a fundamental property of thermodynamics—a physical quantity that governs many chemical and biological phenomena and has applications in various fields. Fluorescent nanodiamonds, gold nanoparticles, and colored latex beads are attracting attention as the most sensitive means of measuring temperature on a nanoscale or microscale.
Fluorescent nanodiamonds are attracting attention as nanoscale temperature sensor tools, which apply research to understand the relationship between temperature and cell function by incorporating them into cells.
In contrast, gold nanoparticles and color latex beads are reporters incorporated into lateral flow immunoassays. In the photothermal detection study of lateral flow immunoassays, the reporters are heated by the green laser, which improves the detection sensitivity. Now this technique can be applied to COVID-19 antigen testing.
This study will focus on temperature experiments using fluorescent nanodiamonds, gold nanoparticles, and colored latex beads.

並列關鍵字

thermometric sensing ； fluorescent nanodiamonds ； lateral flow immunoassay ； gold nanoparticles ； color latex beads

參考文獻

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