- 學位論文
鎳金奈米線製作及其交變磁場引致發熱特性探討
Study on the Fabrication and Magneto-Induction Heating Properties of Nickel-Gold Nanowires
摘要
奈米線近年來於生醫上應用的研究已有許多進展，主要為生物細胞分離、生物感測器、熱炙治療等生醫用途。而在生物醫學領域，同時具有檢測與治療功能的材料是相當有發展潛力與應用價值的。故本研究結合鎳與金以電化學沉積法製備成多功能型奈米線，並將鎳與鎳金奈米線在交變磁場下作發熱測試。 鎳奈米線製備的電鍍時間控制為5分鐘，可得到直徑為0.2 μm 、 長度為1 μm的鎳奈米線。接著本研究將金電鍍於製成的鎳奈米線一端，電鍍時間為25分鐘，可得到金段部分為長度0.3 μm的鎳金奈米線。再以氫氧化鈉去除陽極氧化鋁濾膜 ( AAO )，並將其乾燥成粉末狀以作發熱量測。接下來利用100 kHz的射頻磁場，量測不同重量的鎳奈米線在2 Oe ~ 14 Oe磁場強度下的發熱效率。可觀察到鎳奈米線在不同的外加磁場大小下，重量少的鎳奈米線皆有最佳的發熱效率。 最後比較鎳奈米線與鎳金奈米線在低重量下之發熱效率，得知鎳金奈米線在低外加磁場強度下，其SAR皆較鎳奈米線來得高。此外，本研究更進一步探討平行與垂直外加磁場排列對於發熱效率的差異。由本研究之鎳與鎳金奈米線的發熱特性分析，可以發現鎳金奈米線的一項特性。當在重量少、交變磁場強度低、垂直外加磁場排列的情況下，鎳金奈米線的發熱效果較優。本研究選用的磁場大小處於生物體安全範圍( H∙f < 6.09×10^6 Oe/sec )內，因此可作為未來在熱炙治療方面的應用與參考。
並列摘要
The nanowires have been applied to biomedical applications in recent years, such as cell separation, biosensor, hyperthermia therapy, etc. Materials which can be applied to not only detector but also cure are great potential .In this study, we prepare multifunctional nanowires made of electrochemical deposition composed of nickel and gold and use them for the heating experiment under altering magnetic. In this study, Ni and Ni-Au nanowires were fabricated by electrochemical deposition. The plating time for Ni nanowires was 5 minutes, and we can get Ni nanowires with the diameter of 0.3 μm and the length of 1 μm. For fabricating the Ni-Au nanowires, we plate the end of Ni nanowires with Au 25 minutes to get a Au segment with length of 0.3 μm. After deposition, anodic aluminum oxide (AAO) was removed by NaOH and the nanowires were dried into powders. Next, we measure heating efficiency of different weights of Ni nanowires under 2 - 14 Oe altering magnetic field of 100 kHz. We can observe that the less mass of Ni nanowires has greater heating efficiency under any magnitude of magnetic field. Finally, we compare heating efficiency in a small mass of Ni nanowires with Ni-Au nanowires. We find that the SAR value of the Ni-Au nanowires is higher than Ni nanowires under weak magnetic field. In addition, we discuss heating efficiency under magnetic field parallel and perpendicular to alignment of nanowires. According to the analysis in heating efficiency of Ni nanowires and Ni-Au nanowires, we find a special property of Ni-Au nanowires. When it is a small mass and under low-magnitude altering magnetic field (perpendicular to alignment), Ni-Au nanowires has the better heating efficiency. The magnetic flied we choose is in the safe range of the organisms under the radio-frequency (RF) magnetic field (H∙f < 6.09×10^6 Oe/sec). These results can be the application and the reference for hyperthermia therapy in the future.