人體半月軟骨板的定量量測與微結構研究

人體半月軟骨板在膝關節的恆定上扮演一重要角色，包含身體重量的承載與分散等功能。除此之外，許多研究亦指出半月軟骨板和關節軟骨與早期退化性關節炎發生、演進間之密切關係。近年來，針對軟骨進行定量檢測成為早期退化性關節炎之偵測趨勢，而磁振造影因為屬於一非侵入性之檢查，且定量的T1、T2值量測可以反映出組織結構與分子之變化，是故逐漸廣為使用。然而，半月軟骨板為一非均勻物質，除了不同區域間血液供應與否之差異，其內的纖維走向更是大相逕庭。本研究第一部分即利用MRI針對人體半月軟骨板進行不同區域間的定量T2值量測，來探討在正常年輕族群中，半月軟骨板之T2值是否能反映出區域性之差異與性別間之不同。另一方面，前人發表的研究亦指出，半月軟骨板內部的纖維走向與其對於重量的承受與分散之功能有著密切的關係，但是臨床上因為該組織的特性很難在影像上同時呈現好的訊號與對比，本研究第二部分即透過造影之脈衝程序的改良，使用最小相位脈衝激發搭配放射狀的取樣方式來縮短信號衰減的時間，並搭配有效的脂肪壓抑技術來提升半月軟骨板的對比，初步結果已可呈現出半月軟骨板內部之纖維結構。

關鍵字

磁振造影；退化性關節炎；半月軟骨板

並列摘要

Human meniscus plays an critical role in the stability of knee joint, such as load bearing and distribution. In addition, several reports demonstrated the important relationships among articular cartilage, menisci and osteoarthritis. Recently, quantitative measurement of the knee cartilage is helpful for the early detection of OA. MRI provides a non-invasive method and the quantitative T1 and T2 measurements are useful to reflecting the molecular change of the related architecture. However, human meniscus is not a homogeneous substance, in which blood supply and fiber orientation are quite different according to regional discrepancy. As a result, the first part of our research is using MR T2 measurements to investigate the discrepancy between different zones as well as gender difference. On the other hand, although previous study indicated the significant relationship between fiber orientations of meniscal infrastructure and the functions of load bearing and distribution, it is difficult to simultaneously obtain a high SNR and contrast meniscal images. Therefore, the second part of our research is based on the improvement of the imaging sequence, using minimal RF excitation pulse in conjunction with radial sampling scheme to reduce echo time, and combined with adiabatic fat suppression pulse to improve the image contrast. Our preliminary result demonstrated the feasibility of visualization of meniscal infrastructure.

並列關鍵字

MRI ； Osteoarthritis ； meniscus

參考文獻

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人體半月軟骨板的定量量測與微結構研究

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