產前暴露全氟碳化物與孩童智商的相關性

Prenatal exposure to perfluoroalkyl substances and children’s intelligence quotient (IQ)

劉庭睿(Ting-Jui Liu)

指導教授 ： 陳保中

國立臺灣大學/公共衛生學院/環境與職業健康科學研究所/碩士(2021年)

https://doi.org/10.6342/NTU202103633

摘要

背景/目的
在全氟碳化物 Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS)是環境中常見的持久性有機污染物，像是有全氟辛酸 perfluorooctanoic acid (PFOA)、全氟辛 烷磺酸鹽perfluorooctane sulfonate (PFOS)、全氟壬酸 perfluorononanoic acid (PFNA)及全氟十一酸 perfluoroundecanoic acid (PFUnDA)。全氟碳化物質廣泛存在 且動物研究表明，PFAS 會影響兒童的神經發展與智商，然而產前 PFAS 暴露是 否影響更多兒童的智商得分的影響尚不清楚。
方法
我們的研究使用的族群是來自臺灣出生世代追蹤調查研究(Taiwan Birth Panel Study I)，在出生時收集臍帶血測量全氟碳化物的濃度，用極致液相層析/串聯式 質譜儀分析臍帶血中全氟碳化物的濃度。並在隨訪過程中，我們於孩童七歲時進 行魏氏兒童智力測驗第四版試卷測驗評估兒童智商分數。
結果
在我們的研究中，臍帶血中的包括 PFOA、PFOS、PFNA、PFUnDA 的濃度平均 數分別為 2.33、5.12、7.38 和 16.00 ng/mL。研究族群中的孩童智力測驗分數 intelligence quotient total(IQ total)平均數為 113.0，全量表智商 full scale intelligence quotient (FSIQ)平均數為 109.9。在連續變量迴歸模型中，產前暴露 PFOA 濃度對 於兒童智商分數呈現正相關，且產前暴露 PFOA 濃度對知覺推裡指數(PRI)有統 計顯著(β=12.035, p<0.05);產前暴露 PFUnDA 濃度對於智商分數呈現負相關， 且產前暴露 PFUnDA 濃度對處理速度指數(PSI)指數分數有統計顯著(β=-5.634, p<0.05)。
結論
我們的研究表明，產前暴露 PFOA 及 PFUnDA 與孩童智商有關。暴露 PFOA會影響知覺推裡指數(PRI)和 PFUnDA 會影響處理速度指數(PSI)。產前 PFAS 暴露可能對兒童智力發展有重要作用。這些暴露的健康風險需要更進一步探索。

關鍵字

產前暴露 ； 全氟碳化物 ； 智商 ； 魏氏兒童智力測驗第四版 ； 神經發展

並列摘要

Background/Aim
The Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS), such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUnDA), are common persistent organic pollutants in the environment. Animal studies had indicated PFAS would influence children’s neurodevelopment and intelligence quotient score. However, the effect of whether prenatal PFAS exposures affect more children's intelligence quotient score are unclear.
Aim
The purpose of this study is to explore the relationships between the prenatal exposure of PFAS and total intelligence quotient.
Methods
Our study cohort was 486 mother-infant pairs from Taiwan Birth Panel Study I. During the follow-ups, we using the Wechsler intelligence scale (WSIC-IV) evaluated the information of intelligence quotient in childhood at seven years old. The concentration of PFAS in cord blood were analyzed by ultra-high-performance liquid chromatography/ tandem mass spectrometry.
Results
In our study, the concentrations of PFAS including perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUnDA) in cord blood were 2.33, 5.12, 7.38, and 16.00 ng/mL, respectively. The average child intelligence quotient (IQ total) population was 11, and Full Scale IQ (FSIQ) average was 109.9. In the linear regression model, the prenatal exposure PFOA concentration is positively correlated with the children’s IQ score, and the prenatal exposure PFOA concentration has a statistically significant effect on the Perceptual Inference Index (PRI) (β=12.035, p<0.05); prenatal exposure The concentration of PFUnDA is negatively correlated with IQ scores, and the concentration of PFUnDA exposed to prenatal has a statistically significant effect on the processing speed index (PSI) score (β=-5.634, p<0.05).
Conclusions
Our study showed that prenatal exposure of PFOA and PFUnDA were associated with children IQ. Exposure to PFOA will affect the Perceptual Reasoning Index (PRI) and PFUnDA will affect the Processing Speed Index (PSI). Prenatal PFAS exposure may play an important role in children's intellectual development. The health risks of those exposures need further exploration.

並列關鍵字

prenatal exposure ； perfluoroalkyl substances (PFAS) ； intelligence quotient (IQ) ； Wechsler intelligence scale (WSIC-IV) ； neurodevelopment

參考文獻

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