華中五味子之果實成分研究

Studies on the Constituents of Fruits from Schisandra sphenanthera Rehd. et Wils

蒙貝佳(Khongorzul Mendbayar)

指導教授 ： 沈雅敬

國立臺灣大學/醫學院/藥學研究所/碩士(2011年)

https://doi.org/10.6342/NTU.2011.00813

摘要

無資料

關鍵字

華中五味子

並列摘要

Phytochemical investigation of Schisandra sphenanthera (Schisandraceae) from dichloromethane partition of the acetone extracts led to the isolation of four new sesquiterpenes called schisansphenins A, B, C and D (1, 2, 3, 4) and eleven known compounds such as macelignan (5), 1-(3,4-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-2,3-dimethylbutane (6), chicanine (7), meso-dimethyl dihydroguaraeitic acid (8), schisantherin D (9), 6-O-benzoylgomisin O (10), erythro-austrobailignan-6 (11), gomisin B (12), schisantherin A (13), gomisin G (14) and gomisin C (15).
Structural elucidations for the found compounds were based on spectroscopic analyses such as 1H- and 13C-NMR, including 2D NMR (1H-1H COSY, HMQC, HMBC and NOESY) experiments, and by comparison of their spectroscopic data with those of related metabolites.
The isolated compounds had been tested by dipeptidyl peptidase-4 (DPP-4) inhibition assay. Except erythro-austrobailignan-6 (11), the rest isolated compounds did not show any significant inhibition.

並列關鍵字

Schisandra sphenanthera ； sesquiterpenes ； lignans ； DPP-4 inhibition assay

參考文獻

1. National Diabetes Fact Sheet, 2007. Department of health and human services centeres for disease control and prevention

2. www.worlddiabetesday.org. Unite for Diabetes.

3. Boyle, J.P..; Edward, W. G.; Lawrence, E. B.; David, F.W.; Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Population Health Metrics 2010, 8, 29.

4. 2004–2006 National Health Interview Survey.

5. Ye, S.; Xiangying, W.; Hongwen, H.; Population genetic differentiation of Schisandra chinensis and Schisandra sphenanthera as revealed by ISSR analysis. Biochem. Syst. Ecol. 2010, 38, 257-263