- 學位論文
以微控制器為平台之可程式化生理信號即時監測及麻醉深度回饋控制系統
Microcontroller-based programmable real-time system for the monitoring of physiological signals and for the feedback control of anesthetic depth
摘要
本系統為一個可程式化的生理信號即時監測及麻醉深度回授控制系統，利用此系統達到實驗過程中即時觀察的目的，並經由注射幫浦推進速度之控制作穩定麻醉深度之目的。 本系統包括了生理信號的放大及濾波電路、生理信號的擷取與分析、LCD顯示系統、注射幫浦推進量的回授控制及生理信號的儲存與傳輸等五個部分。利用生理信號的放大及濾波電路，我們可以由血壓波形中分離出心跳、呼吸及平均血壓的信號，將這些生理數據透過LCD顯示，藉由這些生理信號的觀察及分析了解實驗動物之麻醉深度，並經由注射幫浦速度之控制達到穩定麻醉深度，此外記錄到的生理數據亦儲存於本系統的記憶體，實驗後可透過內建的RS232串列通訊埠下載至電腦作進一步之分析。 本系統乃一獨立之設備，除了整合多種儀器之弁鄍~，並不需經由PC操作而具有可程式化的彈性，可依據麻醉藥劑之種類而決定注射速率，對於研究麻醉模型及藥物機制而言本系統是項重要之設備。
並列摘要
This study proposes a home-made system that records physiological signals and controls an infusion pump. It monitors and controls the anesthetic depth. This device is composed of five functional units: an amplifier and filter circuit, an acquisition and analysis unit, a LCD display unit, an infusion pump and its control circuit, and a unit for data storage and transmission. The arterial pressure waveform of the rat was used to identify the heart rate (HR), the mean blood pressure (BP), and the respiratory rate (RR) in real time. These signals are important for monitoring the level of anesthesia. This level can be tuned by controlling the speed of the infusion pump, i.e., controlling the dosage of the anesthetic agent to stabilize the anesthetic depth. A small LCD panel is used in this system for real-time display of the data and trend of these signals. The sampled data were stored in a static RAM for off-line download via the built-in RS232 port of the system to a host computer for complex analysis. The developed system is a stand-alone device. It integrates functions from several instruments. Furthermore, without any intervention from a computer, it provides the flexibility in programmability. According to the anesthetic agent used, the infusion rate can be changed optimally by replacing the PIC16F877 chip. It is an valuable device for the studies on anesthetic model and pharmacokinetic