新穎穿戴式光學裝置用以連續監測眼壓

A Novel Wearable Optical Device for Continuously Monitoring Intraocular Pressure

何智昇(Chih-Sheng Ho)

指導教授 ： 王倫

國立臺灣大學/電機資訊學院/光電工程學研究所/碩士(2015年)

https://doi.org/10.6342/NTU.2015.00670

摘要

連續眼睛曲率變化被稱為眼壓，對於青光眼的患者24小時的連續監控眼睛曲率變化為重要的診斷方法，可是通常眼壓的高峰和低峰值在觀察的當下不一定量的到，所以需要有連續觀察裝置。因此，連續的眼壓監控是普遍用於調控抗青光眼劑的劑量和頻率的必要條件。

在論文中，我們提出一個完全被動的，非侵入性的光學裝置，且可連續監控眼壓。此裝置是利用隱形眼鏡上做結構，再利用兩層疊合形成莫爾條紋進而量測到眼角膜的曲率變化。我們的裝置靈敏度可達到1個毫米汞柱而量測範圍可到20毫米汞柱，藉由我們所拍出的莫爾條紋可分析出１毫米汞柱條紋間距會產生暗紋縮小週期變化。與其他現有眼壓量測裝置去做比較的話，我們的裝置較單純，被動式，沒有嵌入電路，並能用於監測青光眼患者的眼壓變化。

關鍵字

青光眼 ； 隱形眼鏡 ； 眼壓

並列摘要

Continuous ocular dimensional profile, intraocular pressure (IOP), has been known as an important diagnostic method for patients to measure glaucoma over 24hours, nocturnally and diurnally, as well as the number of peaks and troughs diurnally and nocturnally. Consequently, continuous IOP monitoring is required for adjusting the dosage and frequency of anti-glaucomatous agents for each individual.
　　　In this work, a fully passive, non-invasive optical device is proposed for continuous IOP monitoring. The device is composed of a contact lens sensor with double-layered structure which utilizes moiré fringe to characterize the variation of the cornea curvature. Unprecedentedly our device is able to reach 1 mmHg sensitivity over a wide range of 20 mmHg at an increase of spatial period to from the resultant moiré fringe. Compared to other contact lens-based sensors, our device is simple, passive, no imbedded electric circuit, and capable for monitoring the IOP variability of glaucoma patients.

並列關鍵字

Glaucoma ； Intraocular pressure ； Contact Lens

參考文獻

[1] Hattenhauer MG, Johnson DH, Ing HH, Herman DC, Hodge DO, Yawn BP, et al. The probability of blindness from open angle glaucoma. Ophthalmology 1998;105:2099–104.

[4] Goldmann, H. and Schmidt, T. Über Applanationstonometrie, Ophthalmologica, 1957, 134, pp.221-42.

[5] Greene, M. and Gilman, B. “Intraocular pressure measurement with instrumented contact lenses,” Investigative ophthalmology & visual science, 1974, Vol. 13, no. 4, pp. 299-302.

[7] Leonardi, M., Leuenberger, P., Bertrand, D., Bertsch, A., Renaud, P.“First steps toward noninvasive intraocular pressure monitoring with a sensing contact lens,” Investigative ophthalmology & visual science,2004. Vol. 45, no. 9.

[8] Isaac Amidror,Roger D. Hersch,Victor Ostromoukhov. “Spectral Analysis and Minimization of Moiré Patterns in Colour Separation” Journal of Electronic Imaging, 3(3), pages 295-317, 1994.