- 學位論文
左心室向心性再塑型化與心血管疾病檢驗指標及代謝症候群之相關性研究
A Study on the Association of Left Ventricular Concentric Remodeling with the Biomarkers of Cardiovascular Disease and Metabolic Syndrome
若您是本文的作者，可授權文章由華藝線上圖書館中協助推廣。
摘要
研究背景 左心室向心性再塑型化為較初期之心臟血管疾病表徵，其會提高心臟血管疾病的罹病風險、死亡風險，但國內探討左心室向心性再塑型化相關危險因子之研究顯少。 研究目的 本研究欲探討在一般民眾中左心室向心性再塑型化相關危險因子，期提供更多資訊協助臨床醫護人員、公共衛生相關人員在心臟血管疾病預防保健、治療照護工作上，一方面達到減少國人心臟血管疾病罹病率、提升國人健康及生活品質，另一方面期能降低其罹患心臟血管疾病後所帶來的龐大醫療費用。 研究方法 本研究選取台北市某醫學中心之健康檢查中心自2005年10月1日至2008年11月30日止同時進行理學檢查、空腹血糖檢驗、總膽固醇檢驗、三酸甘油脂檢驗、高密度脂蛋白膽固醇檢驗、低密度脂蛋白膽固醇檢驗、高敏感性C反應蛋白檢驗、高半胱胺酸檢驗、原生B型利鈉胜肽檢驗、心臟超音波檢查的民眾共1265位為研究對象，並利用其當次健康檢查資料進行分析研究。 研究結果 綜合研究結果發現，總膽固醇濃度、低密度脂蛋白膽固醇濃度、高敏感性C反應蛋白濃度、高半胱胺酸濃度、原生B型利鈉胜肽濃度、代謝症候群皆為左心室向心性再塑型化之獨立危險因子，而其會增加1.5~2.5倍的左心室向心性再塑型化罹病風險。 結論 期此研究結果對於臨床醫療人員在評估民眾罹患左心室向心性再塑型化有所助益以早日介入治療，進而提升國人健康、降低罹患心臟血管疾病之風險，以及減少心臟血管疾病相關醫療費用。
並列摘要
Background Left ventricular concentric remodeling is a condition of the early cardiovascular disease, and it is associated with markedly increased risk for cardiovascular disease morbidity and mortality. However, the study about exploring the risk factors for left ventricular concentric remodeling in general population was not well established. Objective The aim of the present study is to evaluate the independent risk factors for left ventricular concentric remodeling in general population and expect to provide more information and welfare for prevention, control, treatment and healthcare of cardiovascular disease. Besides to reduce cardiovascular disease morbidity and enhance the health and quality of life of citizens, on the other hand hope to reduce the huge medical expenses for cardiovascular disease. Methods In this study, 1265 consecutive subjects were enrolled in a Health Evaluation Center-based population study (since October 1, 2005 to November 30, 2008). Data including baseline characteristics, physical examination, total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-sensitivity C-reactive protein (hs-CRP), homocysteine, N-terminal prohormone brain natriuretic peptide (NT-proBNP), echocardiography were all collected and evaluated. Results In this study found that total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-sensitivity C-reactive protein (hs-CRP), homocysteine, N-terminal prohormone brain natriuretic peptide (NT-proBNP), and metabolic syndrome (MS) were the independent risk factors for left ventricular concentric remodeling in general population. And people with un-normal total cholesterol, low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, homocysteine, N-terminal prohormone brain natriuretic peptide, and people with metabolic syndrome had 1.5-fold to 2.5-fold increased risk for morbidity of cardiovascular disease. Conclusions Look forward to the results of this study for clinical assessment of people suffering in left ventricular concentric remodeling of the early intervention help the treatment to enhance the health of people, reduce risk for morbidity of cardiovascular disease and the medical expenses causing of cardiovascular disease.
參考文獻
Nestel, P., Lyu, R., Low, L. P., Sheu, W. H., Nitiyanant, W., Saito, I., et al. (2007). Metabolic syndrome: recent prevalence in East and Southeast Asian populations. Asia Pac J Clin Nutr, 16(2), 362-367.
Pan, W. H, Yeh, W. T. & Weng, L. C. (2008). Epidemiology of metabolic syndrome in Asia. Asia Pac J Clin Nutr, 17(s1), 37-42.
Alberti, K. G., & Zimmet, P. Z. (1998). Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med, 15(7), 539-553.
American Association for Clinical Chemistry, Lab Tests Online（2008）：http://www.labtestsonline.org/
American Heart Association（2008）：Heart Disease and Stroke Statistics-2008 Update：http://www.americanheart.org/downloadable/heart/1200082005246HS_Stats%202008.final.pdf
延伸閱讀
- 連文彬、李英雄、張輔仁（1976）。鬱血性心臟衰竭之深入性左心室機能檢查：（II）利用單面快速攝影術測定各種心臟病之左心室容積研究。當代醫學，(27)，66-66。https://doi.org/10.29941/MT.197601.0018
- 許桓瑞（2006）。評估左心室舒張末期血壓－容積與收縮末期血壓之關係與系統開發〔碩士論文，中原大學〕。華藝線上圖書館。https://doi.org/10.6840/CYCU.2006.00011
- 門朝陽、閻紫宸、萬建成、鄭初發、郭傑、莊士易、李明憲（1999）。非一致性衰變校正鉈-201心肌灌注掃描對國人冠心病病灶偵測之研究-與心導管結果相比較。核子醫學雜誌，12(4)，175-180。https://www.airitilibrary.com/Article/Detail?DocID=1022923x-199912-12-4-175-180-a
- Lin, Y. J., Chien, K. L., Chen, H. K., Wang, C. S., & Chu, C. C. (2015). Left Ventricular Dyssynchrony Predicts Left Main Coronary Artery Disease in Patients with Non-ST-Segment Elevation Myocardial Infarction. Acta Cardiologica Sinica, 31(3), 226-231. https://doi.org/10.6515/ACS20150105A
- Aggelopoulos, P., Chrysohoou, C., Pitsavos, C., Papadimitriou, L., Liontou, C., Panagiotakos, D., Tsiamis, E., & Stefanadis, C. (2009). Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome Patients. Mediators of Inflammation, 2009(), 579-585. https://doi.org/10.1155/2009/826297