線蟲小熱休克蛋白HSP16.1的選殖、表現、純化及分子保護活性研究

Cloning, Expression, Purification and Chaperone-like Activity of a Small Heat-shock Protein, HSP16.1, from Caenorhabditis elegans

施駿成(Chung-Cheng Shih)

指導教授 ： 邱式鴻

國立臺灣大學/生命科學院/生化科學研究所/碩士(2004年)

https://doi.org/10.6342/NTU.2004.00563

摘要

當生物體遭到不同逆境壓力刺激時，它們會產生一群小熱休克蛋白。已知小熱休克蛋白具有分子保護活性，可與錯誤摺疊蛋白結合並使它們維持在易摺疊狀態。小熱休克蛋白在結構上的特色是在中間有一段保守不變的

關鍵字

線蟲 ； 小熱休克蛋白 ； 分子保護活性 ； 分子保護者

並列摘要

Small heat shock proteins (sHSPs) form a diverse family of proteins that are produced under various stresses in all organisms. It has been shown that they have chaperone-like activity, which can bind unfolded or misfolded proteins and maintain them in a folding-competent state. The common structural features of small heat shock proteins comprise an N-terminal domain and a C-terminal tail, which flank the evolutionarily conserved

並列關鍵字

small heat-shock protein,chpaerone-like activity, ； molecular chaperones

參考文獻

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