可程式化神經電刺激器-最小能量傳遞達到最大收縮

Programmable electrical nerve stimulator for maximal contraction with minimal energy delivery

何威毅(Wei-Yi Ho)

指導教授 ： 趙福杉

國立臺灣大學/工學院/醫學工程學研究所/碩士(2014年)

https://doi.org/10.6342/NTU.2014.01366

摘要

脊髓損傷(Spinal Cord Injury)造成肌肉癱瘓而使傷者無法完成坐到站(Sit-to-stand)，此為日常生活中最常使用到的動作之一。周邊神經電刺激(Peripheral Nerve Stimulation, PNS)可被用以改善及恢復肌肉的功能，可使肌肉達到最大收縮(Maximal Contraction) – 完成坐到站之前提，然而，其安全性及電刺激參數和肌肉收縮力量之關係尚不清楚。本研究實現一可程式化神經電刺激器，藉由可任意調整參數如電流強度、頻率、Pulse Duration及Burst Duration之特性，以及結合微小化的力感測裝置計算肌肉收縮力量，在牛蛙動物實驗中，找到一組最低能量電刺激參數使肌肉達到最大收縮(Maximal Contraction, MC)，此參數為1 Hz，0.327 mA，6 ms Burst Duration，1 ms Pulse Duration，448.54 μJ。

關鍵字

脊髓損傷 ； 坐到站 ； 周邊神經電刺激 ； 最大收縮 ； 最小能量傳遞

並列摘要

Patients with spinal cord injuries lose their motor control and cannot transfer from sit to stand motion, which is of great importance for mobility and independence in daily life. To assist transfer, maximal contraction of lower limb muscles are necessary and can be achieved by peripheral nerve stimulation. However, the relation between stimulating parameters and force of contraction is not known. In our research, a programmable electrical nerve stimulator with a bi-phasic, constant-current output and a miniaturized force measurement device are implemented. Parameters such as current amplitude, frequency, burst duration, and pulse duration can be adjusted arbitrarily. In animal experiment of bullfrogs, a set of stimulating parameters, 1 Hz, 0.327 mA, 6 pulses with pulse duration of 1 ms, and 448.54 μJ, is found to achieve maximal contraction of gastrocnemius with minimal energy delivery.

並列關鍵字

Spinal cord injury ； Sit-to-stand ； Peripheral nerve stimulation ； Maximal contraction ； Minimal energy delivery

參考文獻

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