人體組織三維生物列印之電腦輔助設計模型建構

本研究之目的為開發電腦輔助設計(CAD)建模工具以建立人體組織三維生物列印模型，並應用在生物醫學領域。首先，以AutoCAD、Visual LISP和DCL語言開發一三維重建工具，以橫截面重建人體組織(包括冠狀動脈、動脈和氣管)之模型。該工具可將橫截面進行曲線擬合，並將各橫截面連接，以產生擬真並具有所需管壁厚度的模型。同時，該工具也可將各橫截面的形心連結產生一條路徑，並使用圓形截面掃略該路徑以建立具更平整表面之簡化模型。除了開發該三維重建工具外，本研究亦開發參數化建模工具，從數學模型建立非球面和非對稱的眼角膜模型。該工具能從輸入的量測參數，建立分層且厚度可設定的角膜模型。最後，本研究開發一程式以處理角膜地形儀之原始資料，並建立一擬真角膜模型。該程式首先由原始資料計算出三維座標並產生一個點資料雲，再藉由該點資料雲建立出角膜之三維模型。藉由本研究開發之工具和程式，建模過程變得自動化且有效率。只要在所開發的工具或程式中設定參數，就能建立擬真或參數化的模型。本研究建立之人體組織模型在生物醫學領域有廣泛的應用，包括人工組織列印、光學模擬、術前規劃和氣流實驗。

關鍵字

電腦輔助設計模型建構；三維重建；參數化建模；三維生物列印；角膜地形圖

並列摘要

The purpose of this study is to develop computer-aided design (CAD) tools to construct 3D bio-printing models of human tissues for biomedical applications. First, a 3D reconstruction tool is developed based on AutoCAD, Visual LISP, and DCL language to construct human tissues (e.g., coronary artery, arteries, and trachea) models from cross sections. The tool can construct mimic models with desired wall thickness by curve-fitting the cross sections and linking them together. Meanwhile, the tool can construct simplified models with more smooth surface by sweeping a circle region over a path which is created by linking the centroids of all cross sections. Beside the 3D reconstruction tool, parametric modeling tools are also designed to construct aspherical and asymmetric cornea models based on mathematical models. The tools would construct layered cornea models with desired thickness by setting measured parameters. Finally, a program is written to process corneal topography raw data and construct a mimic cornea model. The program would first calculate 3D coordinates from the raw data to generate a point cloud and then construct a model based on it. With the developed tools and programs, modeling process becomes both automatic and efficient. Mimic models or parametric models can be constructed by simply setting parameters in the user interface of the tools and programs. The constructed models have a wide range of biomedical applications, including artificial tissue printing, optical simulation, preoperative planning, and gas flow experiments.

並列關鍵字

CAD modeling ； 3D reconstruction ； parametric modeling ； 3D bio-printing ； corneal topography

參考文獻

[4] W. Sun and P. Lal, "Recent development on computer aided tissue engineering — a review," Computer Methods and Programs in Biomedicine, vol. 67, pp. 85-103, 2002/02/01/ 2002.

[6] W. Sun, B. Starly, J. Nam, and A. Darling, "Bio-CAD modeling and its applications in computer-aided tissue engineering," Computer-Aided Design, vol. 37, pp. 1097-1114, 9/15/ 2005.

[7] F. Rengier et al., "3D printing based on imaging data: review of medical applications," International Journal of Computer Assisted Radiology and Surgery, vol. 5, pp. 335-341, 2010.

[8] T. J. Hinton et al., "Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels," Science Advances, vol. 1, 2015.

[10] J. Y. Lee and K. Kim, "Geometric reasoning for knowledge-based parametric design using graph representation," Computer-Aided Design, vol. 28, pp. 831-841, 1996/10/01 1996.

國際替代計量

人體組織三維生物列印之電腦輔助設計模型建構

全文下載

主題瀏覽