Stretchable devices possess a great potential in the deformation of electronic devices, medical research and human-computer interaction technology, which will be omnipresent in future wearable technologies. However, the high strain sensitivity of stretchable transistors still remains as a challenge issue. In this thesis, a stretchable organic thin-film transistor combined with the stacked piezoresistive nanocomposite material PU-PEDOT:PSS/AgNWs/PU-PEDOT:PSS has been proposed and fabricated. We have successfully demonstrated that the stretchability and sensitivity of this newly designed device can be enhanced compared with previous reports. The approach shown here is very useful for the development of high performance soft electronic devices with practical applications.