In the present article, we study the large deviation property of the generalized symmetric exclusion process. Once the hydrodynamic limit, which corresponds to a space-time law of large numbers type result, of a Markov process has been established, a natural step is to consider the large deviations from the limit. Kipnis, et al. derived the hydrodynamic limit of a generalized symmetric exclusion process, which is a non-gradient system. We then derive the large deviation principle of this model.