擴散光學斷層掃瞄術：系統設計以及臨床量測研究

Diffuse Optical Tomography: Optode Design and Clinical Study

吳峻名(Chun-Ming Wu)

指導教授 ： 蔡睿哲

共同指導教授 ： 孫家偉

國立臺灣大學/電機資訊學院/光電工程學研究所/碩士(2007年)

https://doi.org/10.6342/NTU.2007.00954

摘要

本篇論文中設計了一套擴散光學斷層掃瞄術的系統，擴散光學斷層掃瞄術是利用近紅外光來觀測生物體內吸收係數、散射係數分佈的一套技術，能精確地描繪出生物組織中含氧血紅素、缺氧血紅素濃度以及血氧飽和度的變化狀態。
以軟性電路板作為主要的底材，將光源與光偵測器以棋盤式的幾何位置安置於其上，利用時間多工的方式使光源輪流發亮，再擷取光檢測器上的光強度作為影像重建的資料來源。
文中對健康的案例及一些加護病房中的病患做了一些生理量測實驗，主要是在靜脈束縛的觀察上，得到的實驗數據與真實的生理資訊有相當程度的對應性，且在特定病例上能看出與常人的差異性。

關鍵字

擴散光學斷層掃瞄術 ； 近紅外光光譜學 ； 醫學造影 ； 造影系統

並列摘要

Diffuse optical tomography (DOT) is the technique that probes and images spatial variations in absorption and scattering properties of the biological tissues. DOT can accurately measure simultaneous changes in concentrations of oxy-hemoglobin and deoxy-hemoglobin. The oxygenation images have been reconstructed by the measured hemodynamics signals with nearest-neighbor pairs of sources and detectors. In our study, a portable DOT system is built with optode design on flexible print circuit board (PCB). The DAQ card is used to PC connection for multiplex driving of laser diodes and detected signal process form photodiodes on optode in DOT system.
In this thesis, the principles and systematic designs of DOT are demonstrated. In experiments, the excise and vessel occlusion hemodynamics are observed with in vivo measurements form normal subjects and some patients in intensive care unit.

並列關鍵字

Diffuse optical tomography ； Near-infrared spectroscopy ； Medical imaging ； Imaging system

參考文獻

[1] C. -W. Sun, Probing Biological Tissues and Phantoms with Quasi-coherent Polarized Light Based on Ultrafast Lasers, Ph.D thesis, National Taiwan University, R.O.C., 2003

U. Netz and J. Beuthan, Near-infrared diffuse optical tomography, Disease Markers, Vol. 18, p. 313–337, 2002, IOS Press

[16] Claudia Casavola Lelia, Adelina Paunescu, Sergio Fantini, Enrico Gratton, Blood flow and oxygen consumption with near-infrared spectroscopy and venous occlusion: spatial maps and the effect of time and pressure of inflation, Journal of Biomedical Optics, Vol. 5(3), 269–276 (July 2000)

[17] Danny K. Joseph, Theodore J. Huppert, Maria Angela Franceschini, and David A. Boas, Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging, APPLIED OPTICS, Vol. 45, No. 31, p. 8142, 1 November 2006

[18] Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Christine Kogel, Sandra Soho, Subhadra Srinivasan, Xiaomei Song, Tor D. Tosteson, Steven P. Poplack, Keith D. Paulsen, Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes, Journal of Biomedical Optics, Vol. 9(3), 541–552 (May/June 2004)