評估使用乙醯檸檬酸三丁酯及超分支聚酯之新式組織調理材的黏著強度

組織調理材(tissue conditioner)常用於活動義齒暫時墊底,可舒緩因其組織接觸面(tissue surface)與口腔黏膜間的不密合所引起的不適感,目前臨床使用上最大問題是組織調理材所含之酯類增塑劑及乙醇會釋出導致這類材料黏彈性質(viscoelasticity)隨著口內使用時間拉長而快速喪失。為延長組織調理材黏彈性質的維持時間及減少生物毒性成份的使用,先前本研究團隊以無毒環保增塑劑—乙醯檸檬酸三丁酯(acetyl tributyl citrate, ATBC),另加入分子量較大之超分支聚酯(hyperbranched polyester, TAH)以減少增塑劑的釋出,進而減少組織調理材料黏彈性質的喪失。結果顯示使用液劑為 78.3wt% ATBC、8.7wt% TAH 和 13wt%乙醇之新式組織調理材(NTU-TC),其複數剪切模數(G*)的28天模擬口腔環境中,百分比變化量為所有組別中最小,故認為此新式組織調理材(NTU-TC)有較長時間的黏彈性質穩定表現。為使之臨床應用的可能,此類材料與活動義齒間使用後黏著失效的現象必須要被進行探討。因此,組織調理材與活動義齒的黏著強度(bonding strength)是本研究探討的重點:針對新式組織調理材(NTU-TC)及兩組市售組織調理材(Soft liner,GC; Lynal,Dentsply),與常用於活動義齒基底之材料:PMMA樹脂(Lucitone 199,Dentsply)進行樣品裝配,在分組給予不同天數(Day 0, 1, 3, 7, 14, 28)的 37°C水中浸泡後進行抗張黏著強度(Tensile bonding strength)測試,並觀察黏著失效模式(Failure mode)。結果顯示,所有組別的抗張黏著強度均隨著浸泡時間的增長而有增加的趨勢。除Day 0外,NTU-TC在Day 1到Day 28都保持穩定的黏著強度;在黏著失效模式上,所有組別之樣品均呈現膠合面失效(adhesive failure)。故本研究認為新式組織調理材(NTU-TC)在與活動義齒基底有合理之黏著性質。

關鍵字

組織調理材；抗張黏著強度；超分支聚酯

並列摘要

Tissue conditioners are often used in edentulous patients to treat lesions of the alveolar mucosa caused by ill-fitted dentures. The main problem in clinical use is the rapid loss of viscoelasticity due to the leaching of ester plasticizer and ethanol. For extending the life span of tissue conditioner and decrease the using of bio-toxic components, our research team had used acetyl tributyl citrate (ATBC), which are non- toxic and adding hyperbranched polyester (TAH) with large molecular weight to reduce the plasticizer leaching to oral cavity and the loss of viscoelastic property. The results showed that the viscoelasticity stability of new tissue conditioners using using ATBC 78.3%, TAH 8.7% and ethanol 13% as plasticizer was better than another conventional brands. The changes in the percentage of complex modulus (G*) with time for new tissue conditioner was the smallest of all the groups. Therefore, in this study, this new tissue conditioner is the most suitable combination for tissue conditioners. In order to explore the possibility of clinical using, the bonding failure from denture must be discussed. Our research point is the bonding strength between tissue conditioner and denture resin. We would assess the tensile bonding strength between tissue conditioners(NTU-TC, Lynal, Soft liner) in the simulations of oral cavity, immerse in 37°C distilled water, for several days(Day 0, 1, 3, 7, 14, 28). The bonding failure mode would be observed. The results showed the tensile bonding strength of all groups increase with immersion time. Except Day 0, NTU-TC had stable bonding value from Day 1 to Day 28. All samples of three tissue conditioners had adhesive failure mode. We think the new tissue conditioner(NTU-TC) had suitable bonding property with denture resin.

並列關鍵字

Tissue conditioner ； Tensile bonding strength ； Hyperbranched polyester

參考文獻

1. McCabe, J.F., Soft lining materials: composition and structure. J Oral Rehabil, 1976. 3:273-8.

2. Amin, W.M., Fletcher, A.M.,Ritchie, G.M., The Nature of the Interface between Poly(Methyl Methacrylate Denture Base Materials and Soft Lining Materials. J Dent, 1981. 9:336-346.

3. McCarthy, J.A.,Moser, J.B., Mechanical properties of tissue conditioners. Part I: theoretical considerations, behavioral characteristics, and tensile properties. J Prosthet Dent, 1978. 40:89-97.

4. Starcke, E.N., Jr., Marcroft, K.R., Fischer, T.E.,Sweeney, W.T., Physical properties of tissue-conditioning materials as used in functional impressions. J Prosthet Dent, 1972. 27:111-9.

5. Rodrigues, S., Shenoy, V.,Shetty, T., Resilient liners: a review. J Indian Prosthodont Soc, 2013. 13:155-64.

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評估使用乙醯檸檬酸三丁酯及超分支聚酯之新式組織調理材的黏著強度

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