耳蝸外電刺激聽神經之可行性研究

The feasibility study of electronic stimulating cochlear nerve outside the cochlear

鄒宗杰(Tsung-Chieh Tsou)

指導教授 ： 周元昉

國立臺灣大學/工學院/機械工程學研究所/碩士(2014年)

https://doi.org/10.6342/NTU.2014.02304

摘要

現行的人工電子耳，透過外科手術將電極陣列植入耳蝸內，而手術伴隨著相當的風險，風險的主因來自於電極植入耳蝸內，造成無法控制的傷害；欲避開手術風險，則必須設計能夠不須植入耳蝸，從耳蝸外刺激到聽神經的人工電子耳，而首要的目標就是找到從耳蝸外用電刺激到聽神經的方法。
本文設計多種電極，電極的材料是鉻金膜，鉻金膜鍍在薄膜(成分PET)上，透過微機電製程的方式完成電極本體；電極完成後進行動物實驗，實驗動物為天竺鼠，透過手術將天竺鼠外耳、中耳移除後，裸露出耳蝸，將電極置於耳蝸上，試圖從耳蝸外的耳骨上、或是卵圓窗(Oval window)的窗口刺激到聽神經，並使用ABR(Auditory Brainstem Response)量測神經動作電位反應。

關鍵字

人工耳蝸 ； 耳蝸外電刺激 ； 聽神經動作電位

並列摘要

Current cochlear implants surgically implanted electrodes in cochlea. However, there are significant risks of surgery due to the surgically damage in cochlea. If we can stimulate the cochlear nerve outside cochlear, the significantly risk of surgery can be reduced.
In this article, a lot of variety of Cr-Au film electrodes produced by MEMS are designed for a series of experiments on Guinea pigs. Through the surgery the outer and middle ear of Guinea pigs are removed and then set the electrodes on the outer of cochlear attempting to stimulate the cochlear nerve from the bone of cochlear or from the surface of Oval window with ABR to detect the response of cochlear nerve.

並列關鍵字

Cochlear implant ； stimulating cochlear nerve outside the cochlear ； auditory brainstem response

參考文獻

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