自然呼吸狀態下液滴在鼻腔內的附著情況之實驗建構與研究

Experimental construction and study of adherence of drops to the nasal cavity under natural breathing station

吳宗殷(Zong-Yan Wu)

指導教授 ： 周元昉

國立臺灣大學/工學院/機械工程學研究所/碩士(2015年)

https://doi.org/10.6342/NTU.2015.02079

摘要

隨著經濟的成長與城市建設逐漸發展，導致呼吸相關的疾病增加，而鼻腔給藥有著吸收迅速、起效快，且非肽類藥物在鼻腔的吸收速度接近靜注，與使用方便的特點相結合，非常適於急救、自救等優點，對於治療複雜結構的鼻腔內疾患也有著莫大的幫助。
本文主要探討粒徑7um以及10um左右的粒徑大小在自然呼吸狀態下在鼻腔內的分佈狀態，首先利用3D列印技術製作鼻子模型，並使用顯影劑水溶液作為霧化液以便在實驗後進行CT掃瞄，以便了解霧化液滴在自然呼吸狀態下於鼻腔內的分布區域，並製作呼吸管路以減少液滴動量所造成的影響，增加實驗的準確性。

關鍵字

3D列印 ； 顯影劑 ； CT掃瞄 ； 液滴沉積 ； 超音波霧化器

並列摘要

Economic growth and the gradual development of urban construction result in increasing respirayory-related diseases.Nasal administration takes an advantage of rapid absorption and onset to use for first aid and self-help suitably. Nonpeptidic drugs absorption rate in the nasal cavity also close to intravenous injection.So,it is easy for nasal administration to treat to disease in the nasal cavity of complex structures and that has great help for treatment.
This paper mainly discusses 7um and 10um particle size drops adhering to the nasal cavity
under natural breathing station.First,taking 3D printing technology to produce nose model and using a developer solution as atomized liquid so that understanding atomized droplets distribution area in the nasal cavity under natural breathing station through CT scan after the experiment.Furthermore in order to increase the accuracy of the experiment,we also make the breathing circuit to reduce the momentum caused by the droplets.

並列關鍵字

3D printing ； Developer ； CT scan ； Droplet deposition ； Ultrasonic Nozzle

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