This research focuses on the comparison of effectiveness between BIM-based QTO method and Traditional method, in terms of these method’s suitability on Vietnam cost estimation process and the accuracy of quantity results extracted of these two approaches. Therefore, to conduct the comparison of these two technique’s suitability on the QTO and cost estimates in Vietnam, an online survey was distributed in order to find out the perspective of two group of people: People applying Traditional method (Group 1) and People applying BIM-based QTO method (Group 2). At the same time, a case study was conducted to compare and evaluate the accuracy of quantity results extracted from the Traditional method and BIM-based QTO method. Overall, the study indicated that BIM-based method and Manual QTO method both have their own strong points. BIM-based takeoff technique surpasses manual takeoff measurement in terms of Visualization, Reduction of measurement mistakes, and Ability to update and synthesize information. Meanwhile, these criterions “Compatibility with Vietnam construction norm system” and “Suitability for quantities appraisal” are the aspects that made Conventional takeoff method defeats the BIM-based method - this can be explained why the manual method using 2D drawings is currently the most popular method in use in Vietnam, instead of Automated BIM-based method. In addition, the study’s result showed that if the modeling process was completed properly, the quantity returned from the BIM model are, in most situations, as accurate as conventional methods and are unaffected by human mistake in the QTO process.