臭氧及臭氧/紫外光對Mefenamic acid去除影響之研究

The Removal of Mefenamic acid from Water by Ozonation and O3 /UV

劉子瑜(Tzu-Yu Liu)

指導教授 ： 蔣本基

共同指導教授 ： 張怡怡

國立臺灣大學/工學院/環境工程學研究所/碩士(2010年)

https://doi.org/10.6342/NTU.2010.02816

摘要

摘要
甲芬納酸 (Mefenamic acid )為一種非常廣泛使用的非類固醇抗發炎藥物，甲芬納酸為雙酚胺的衍生物物種之一，雙酚胺已被歐盟列為首要重點污染物，主要原因為雙酚胺相關衍生物暴露於水體環境中可造成部分的毒性危害，許多研究調查指出甲芬納酸可被許多污水處理廠檢測出微量濃度，主要原因為甲芬納酸無法完全被污水處理廠有效去除。因此，評估微量甲芬納酸存在環境水體之問題應被重視。
本研究目的在於評估臭氧及臭氧/紫外光處理程序對甲芬納酸去除的影響。評估不同的操作條件，例如：臭氧劑量、pH、UV紫外光、水中添加鹼度及腐殖酸對甲芬納酸去除影響之調查。更進一步研究，臭氧副產物生成潛勢。同時發展甲芬納酸降解預測模式，可決定反應動力常數與解釋甲芬納酸降解機制。最後利用最佳化設計結合反應取面法決定實驗最佳化設計之參數。
研究結果顯示出利用臭氧及臭氧/紫外光處理程序可有效的去除甲芬納酸。在臭氧及臭氧/紫外光處理程序中，提高臭氧劑量與降低pH可明顯提高甲芬納酸去除率。水中添加基質，例如：腐殖酸，會降低甲芬納酸去除率。甲芬納酸降解預測模式，在臭氧/紫外光處理程序中，成功可決定甲芬納酸反應速率常數。更進一步研究指出，在紫外光處理程序中，臭氧副產物醛類生成濃度隨操作條件pH增加而增加生成量，主要原因為較有多氫氧自由基，容易將有機物質氧化成小分子醛類物質。最後利用反應取面法可得知影響甲芬納酸降解的重要參數為臭氧劑量、pH、反應時間與腐殖酸添加濃度。

關鍵字

甲芬納酸 ； 雙酚胺衍生污染物 ； 臭氧 ； 臭氧/紫外光操作程序 ； 臭氧副產物 ； 最佳化

並列摘要

Mefenamic acid (MEF) is a widely used anti-inflammatory drug. MEF is a diphenylamine derivative pollutant (DPA) which is the third compound in the European Union list of priority pollutants, because of its harmful properties with numeral toxic derivatives being observed in the aquatic environment. Many investigations have revealed that MEF can not be completely removed by conventional sewage treatment plants (STP) and was detected in STP effluents at trace levels. Therefore, the presence of MEF in the aquatic environment should be assessed critically.
The objective of this study was to evaluate the removal of MEF using ozonation and O3/UV processes. The effect of various operating parameters including ozone dose, pH, light intensity (UV), alkalinity, and humic acid on the removal of MEF in ozonation and O3/UV processes was investigated. In addition, the formation of ozonation by-products was also studied. Meanwhile, a simplified model based on MEF decomposition was developed to determine the reaction rate constants of MEF and to interpret the degradation of MEF. Finally, a response surface method was used to evaluate the effect of operation parameters on the degradation efficiency of MEF by ozonation and O3/UV processes.
The results show that ozonation and O3/UV processes were efficient in degrading MEF. In both processes, increase of ozone dosage and decrease of pH enhanced MEF removal. The presence of humic acid can reduce MEF removal also. The MEF degradation model can predict the MEF degradation well. The reaction rate constants of MEF can be determined in a second order reaction. In addition, the aldehyde concentration increased with increasing pH in the ozonation process, which indicated the involvement of hydroxyl radical in aldehyde formation. By using the response surface method, it was found that MEF degradation was sensitive to factors such as ozone concentration, pH, reaction time, and humic acid concentration.

並列關鍵字

Mefenamic acid ； Diphenylamine derivative pollutant ； Ozonation ； O3/UV process ； Ozonation by-product ； Optimization

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