藉由混合官能基之自組裝單層膜調控矽基材的
表面電位與功函數

以高分子系統傳送藥物分子的技術，已經廣泛地被應用在具針對性與選擇性的藥物輸送方面，然而，在已經被報導的系統中，藥物分子大多數會與基材產生特定的共價鍵結，因此，其分子的選擇性較少且不易釋放。本研究利用具有表面混合官能基的自組裝單層膜，經由選擇不同的官能基與不同的混合比例，可以調整固體基材的等電位點、功函數等表面特性，且根據靜電吸脫附的概念，材料在等電位點附近會帶有不同的表面電性，分子可因環境酸鹼值不同而觸發其吸附或脫離，因此，與高分子系統相較之下，以此概念設計的藥物輸送平台有著更大的彈性空間與發展潛力。另一方面，對於光電材料而言，自組裝單層膜的應用也成功地改善光電元件中材料的連接面性質並可調控半導體的功函數值，此表面修飾技術讓元件效率能獲得提升，而矽為最常用的光電材料，且其生物相容性高並價格便宜，所以本研究選用矽烷與矽基材的自組裝單層膜系統，以不同比例的H2N(CH2)3Si(OCH3)3和HS(CH2)3Si(OCH3)3混合生成自組裝單層膜，來調控矽基材的等電位點和功函數。實驗結果顯示，此兩種藥品能在pH值2.24到7.94之間調整矽基材表面的等電位點，並可在4.02到4.99電子伏特之間微調控其功函數值。

關鍵字

自組裝單層膜；混合官能基；表面電位；等電位點；功函數

並列摘要

Bio-degradable polymers have been widely applied in the drug delivery, which has drug targeting specificity and selectivity. Most of these drug molecules are covalently bonded with the polymers and cannot be released easily. In this research, materials modified by self-assembled monolayers (SAMs) of multiple functional groups are prepared and studied. By depositing SAMs of different functional groups in different ratios, the properties of solid substrate, such as the isoelectric point (IEP) and work function, can be tuned. Through the difference in electrostatic interactions, molecules could be either adsorbed or desorbed with the surface of substrate by changing the environmental pH around the selected IEP. In comparison to the polymer-based system, the drug deliver platform using electrostatic interactions has more potential in development. In addition, the application of SAMs can also control the interface properties of opto-electronic devices and regulate the work function of materials that in turn affect the injection of charge carriers. The benefit of enhancing the device efficiency can be expected. As a commonly-used opto-electronic and high biocompatible material, silicon is used as the substrate in this work. The surface of silicon substrate is tailored with different ratios of H2N(CH2)3Si(OCH3)3 and HS(CH2)3Si(OCH3)3 in order to regulate its IEP and work function. The experimental results revealed that the IEP of silicon substrate can be adjusted from pH 2.24 to 7.94, and its work function can be fine-tuned between 4.02 and 4.99 eV.

並列關鍵字

SAMs ； mixed functional groups ； surface potential ； IEP ； work function

參考文獻

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2. Shyue, J.J. and M.R. De Guire, Deposition of titanium-vanadium oxide thin films on organic self-assembled monolayers: Role of complexing agents. Chemistry of Materials, 2005. 17(22): p. 5550-5557.

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藉由混合官能基之自組裝單層膜調控矽基材的表面電位與功函數

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