微流道中紅血球形變與流場分析

RBC Deformation and Flowfield Analysis in Micro-Fluidic Channel

徐良瑋(Liang-Wei Hsu)

指導教授 ： 朱錦洲

國立臺灣大學/工學院/應用力學研究所/碩士(2005年)

https://doi.org/10.6342/NTU.2005.02434

摘要

利用微流體系統進行生醫檢測、病理分析、化學成分偵測等方面的快速檢測晶片，是微全分析系統(Micro Total Analysis Systems , µTAS)近年來的重要發展方向，而設計更為準確、快速、便宜優點的醫用檢測晶片更是擁有迫切的需求。
紅血球在人體綿密的血管網絡中穿梭，經過微血管時會有擠壓變形的現象產生。而研究已發現多項疾病（如：糖尿病）會影響紅血球的彈性及變形能力。本研究利用紅血球有擠壓變形的彈性，使用具有高生物相容性、高透明度、高安定性等優點的高分子聚合物：聚二甲基矽氧烷（PDMS）為實驗測試段，製備微血管尺寸的微流體系統，以觀測紅血球變形現象，及流道幾何特性（如：尺寸、曲率、形狀）對變形率的影響。
初步建立正常血球的實驗資料後，進一步發展成為能以物理性質即時分辨紅血球是否罹病的快速檢驗晶片。

關鍵字

紅血球 ； 變形 ； 微流道

並列摘要

One of the most important development in micro total analysis system (µTAS) is applications of rapid test chip in several aspects like biomedical examines, pathology analysis, and chemical constituent detection. It’s a pressing demand to design a clinical test chip with the advantage of accuracy, rapid, and cheap.
Red blood cells (RBC) shuttle through the close, numerous vessel networks among human bodies and deform shape when getting past blood capillaries. It is found that many diseases affect the elasticity and deformability of RBC. This study makes use of RBC deformable elasticity and introduces an effective micro-fluidic-system composed of high-compatible, high-transparent, and high-stable Polydimethylsiloxane (PDMS) in blood capillaries scale to observe RBC deformations and effects of channel geometry.
After setting up normal RBC experimental data, we attempt to develop a rapid test chip capable of distinguishing RBC ill or not.

並列關鍵字

RBC ； deformation ； PDMS

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