靶向性超音波對比劑之製備與應用

具有分子靶向性的對比劑除了具有將傳統醫學影像更進一步推向分子層次外，也對臨床的診斷和治療開啟了新的契機。靶向性對比劑的製作取決於對比劑本身的性質與所探討的生醫議題相對應的分子。透過新興生物技術的發展，超音波靶向性對比劑可以被應用在癌症血管新生及血栓生成的診療上。本文的目的即在於發展靶向性對比劑應用在此兩議題上。血管新生提供癌細胞成長及轉移所需的養分和路徑，因此被視為癌症治療上不可或缺之標的。而利用各種藥物抑制癌症血管新生則被視為臨床癌症治療的曙光，但如何有效的評估新生血管被抑制的狀況，仍是目前一大研究課題。本研究即利用在癌症部位新生血管表面過度表現的蛋白質

關鍵字

靶向性對比劑；分子影像；癌症；腫瘤血管新生；血栓生成；超音波輔助血栓溶解；穴蝕效應

並列摘要

Molecularly targeted contrast agents will not only broadly extend conventional anatomical imaging into molecular imaging, but also create new opportunities on therapy. Preparation of targeted contrast agents depends on both physical properties of contrast agents and the conjugated biological molecules. Ultrasonic molecular imaging of angiogenesis in cancer and thrombosis has been intensively studied thanks to the rapid discovery of novel biomarkers and affinity ligands. The purpose of this study therefore is to develop targeted ultrasound contrast agents able to recognize thrombi and tumor angiogenesis. Angiogenesis recently has been extensively studied because it is the source of nutrition and metastasis for tumor cells.　Anti-angiogenic therapy, which makes use of angiogenic inhibitors to suppress this mechanism, provides a new way for cancer treatment. However, the lack of effective techniques to assess angiogenesis efficiency impedes fundamental researches and clinical diagnoses. Ultrasonic molecular imaging of tumor angiogenesis may be a potential solution. To construct an ultrasonic imaging system for angiogenesis, endothelial surface proteins,

並列關鍵字

Targeted ultrasound contrast agent ； Molecular imaging ； Cancer ； Angiogenesis ； Thrombosis ； Ultrasound-assisted thrombolysis

參考文獻

[55] 鄭雅健 (2007) 超音波微氣泡之製備與生醫應用。國立台灣大學電機所碩士論文。

[83] 賴俊延 (2005) 超音波穴蝕效應於基因傳遞效率之研究。國立台灣大學電機所碩士論文。

[85] 王慈吟 (2006) 微氣泡輔助之穴蝕效應與超音波治療之應用。國立台灣大學電機所碩士論文。

[1] Massoud TF, Gambhir SS. (2003) Molecular imaging in living subjects: seeing fundamental biological processors in new light. Gen Devel 17(5): 545-580.

[2] Turnbull DH and Foster FS. (2002) In vivo ultrasound biomicroscopy in developmental biology. Trends Biotechnol 20: S29–S33.

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靶向性超音波對比劑之製備與應用

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