1.先生的飲酒行為是產後婦女生活品質的危險因子 2.應用極致液相層析/串聯式質譜儀分析人體血漿中之全氟碳化合物 – 初步研究

1.Husbands’ drinking behavior as a risk factor of wives’ health-related quality of life in the postpartum period 2.Determination of perfluorinated compounds in human plasma using ultra performance liquid chromatography–tandem mass spectrometry – preliminary study

吳禮堯(Li-Yao Wu)

指導教授 ： 陳保中

國立臺灣大學/公共衛生學院/職業醫學與工業衛生研究所/碩士(2009年)

https://doi.org/10.6342/NTU.2009.10684

摘要

無資料

關鍵字

健康相關的生活品質 ； 先生的飲酒行為 ； 產後婦女 ； 全氟碳化合物 ； 極致液相層析/質譜/質譜儀 ； 全氟辛烷磺酸 ； 全氟辛酸 ； 血漿

並列摘要

1. ABTRACT
Purpose: The objective of this study is to investigate the association between husbands’ alcohol drinking and wives’ HRQOL in the postpartum period.
Methods: We used multistage stratified systematic sampling to recruit 24,200 pairs, postpartum women and newborns, from the Taiwan national birth register in 2005. A structured questionnaire was successfully administered to 87.8% of the sampled population. Subjects undertook a home interview 6 months after their deliveries between June 2005 and July 2006. The Medical Outcomes Study 36-item Short-Form (SF-36) was used to measure the quality of life of the women with their husbands’ alcohol drinking behavior.
Results: After controlling for the potential confounders, there were significantly gradual decreases in wives’ scores of SF-36 scales other than physical functioning along with the increase in frequency of husbands’ alcohol drinking. There were significantly gradual decreases in wives’ scores of SF-36 scales other than physical functioning and role-physical along with the increase in frequency of husbands’ alcohol drinking either in primiparous or multiparous women
Conclusions: Our study adds evidence supporting the adverse effect of husbands’ alcohol drinking on women’s health as measured by the SF-36 HRQOL.

2. ABTRACT
Purpose: The aim of this study was to develop a sensitive, convenient and accurate method by using UPLC-MS/MS for a broad range of PFCs for studies involving large sample series.
Methods: We analyze the perfluorinated compounds by using ultra performance liquid chromatography－tandem mass spectrometry with protein precipitation and matrix-matched calibration method. And seven samples of plasma from TBPS were analyzed to investigate the applicability of this validated method.
Results: Perfluorinated compounds were detected in all seven plasma samples. The average concentration of PFOS and PFOA were 31.25 ng/mL and 3.52 ng/mL. Moreover, UPLC provides significantly reduced analysis time and improved chromatographic behavior for PFCs compared with traditional LC.
Conclusions: The low sample volume needed, the limited time consuming and the broad range of analytes which are included, make this method advantageous for large-scale epidemiological studies. Besides, this sample preparation technique and matrix-matched calibration method can easily be set up on standard LC-MS/MS
instruments and is thus available to a wide range of laboratories.

並列關鍵字

health-related quality of life ； husbands’ drinking behavior ； postpartum women ； Perfluorinated compounds ； PFOS ； PFOA ； UPLC/MS/MS ； Plasma

參考文獻

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. Dawson, D.A., Grant, B.F., & Chou, S.P., et al. (2007). The impact of partner alcohol problems on women’s physical and mental health. Journal of Studies on Alcohol and Drugs, 68, 66–75.