結合非溶劑誘導相分離與電紡絲技術製備生物可降解孔洞纖維

Preparation of Biodegradable Porous Fibers by Combining Nonsolvent-Induced Phase Separation and Electrospinning Method

鐘筱崴(Hsiao-Wei Chung)

指導教授 ： 童世煌

國立臺灣大學/工學院/高分子科學與工程學研究所/碩士(2017年)

https://doi.org/10.6342/NTU201702222

摘要

連續性纖維的製程不勝枚舉，其中電紡絲技術屬於簡單的方式。電紡絲纖維尺寸通常可由微米小至奈米等級，具有高比表面積的性質，若能在電紡絲纖維上製造出孔洞，就能再進一步提高纖維的比表面積。一般而言，透過改變電紡絲環境中的濕度能製造出纖維上的孔洞，但是這種孔洞的深度淺，只生於表面，效果十分有限。
　　本實驗利用聚乳酸(PLA)和聚己內酯(PCL)製備高分子電紡絲纖維，搭配溶劑三氯甲烷(CF)和氯苯(CB)、非溶劑二甲基亞碸(DMSO)，成功透過非溶劑誘導相分離法(nonsolvent-induced phase separation, NIPS)於三相系統中獲得一系列不同孔洞型態的電紡纖維，調配非溶劑含量的比例，纖維上的孔洞有明顯的變化，PLA系列的纖維孔洞大小可由50奈米變化至1200奈米，而PCL系列的纖維孔洞大小可由500奈米變化至3200奈米。我們也發現，無論是PLA還是PCL高分子孔洞纖維，使用沸點較高的CB作為溶劑，該系統的電紡纖維表面孔洞會比CF系統大。
　　另外，我們也利用其他不同的溶劑與非溶劑組合，嘗試找出能製備孔洞纖維的最佳條件，進一步發現溶劑除了要能與非溶劑互溶，沸點亦不能接近或高於非溶劑；而非溶劑除了沸點高之外，還要具備與水互溶的特性，才有利於產生孔洞纖維。

關鍵字

電紡絲 ； 非溶劑誘導相分離 ； 生物可降解高分子 ； 孔洞纖維 ； 聚乳酸 ； 聚己內酯

並列摘要

The electrospinning is a simple way to fabricate fibers in a continuous manner, which generates fibers with a high specific surface area due to the small diameters ranging from nanometers to several micrometers. To further increase the specific surface area, one can create pores on the electrospinning fibers. The humidity of environment can be used to produce pores on the fibers through the condensation of moisture, but the pores formed by this way only occur on the surface and are generally small and shallow. Therefore, the increase of the specific surface area of fibers by raising the humidity is limited.
In this study, biocompatible poly (lactic acid) (PLA) and polycaprolactone (PCL) were used for preparing electrospinning polymer fibers. Chloroform (CF) or chlorobenzene (CB) was used as solvent, and dimethyl sulfoxide (DMSO) was chosen as nonsolvent. The polymers were dissolved in the mixture of the solvent and nonsolvent, and the ternary systems were successfully electrospun into a series of porous fibers by nonsolvent-induced phase separation (NIPS). The pore size and the pore morphology are changed significantly by adjusting the ratio of the nonsolvent in the mixtures. The pore size of the PLA fibers is 50 to 1200 nm and that of the PCL fibers is 500 to 3200 nm. The higher boiling point CB as solvent causes larger pores than CF in both PLA and PCL fibers. More importantly, the pores not only form on the surface, but can penetrate into the fibers for the mixtures with appropriate amount of the nonsolvent.
We also utilized the combinations of other solvents and nonsolvents to establish the principles for producing porous fibers. We found that to successfully produce porous fibers, the solvents and the nonsolvents must be miscible and the boiling point of the solvents must be lower than the nonsolvents. In addition, a good miscibility of the nonsolvents with water favors the pore formation.

並列關鍵字

Electrospinning ； nonsolvent-induced phase separation ； Biodegradable polymer ； Porous fibers ； PLA ； PCL

參考文獻

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