The 1st Part: An efficient Cu-catalyzed O-arylation was carried out by involving phenols with iodoarenes to afford various substituted diarylether derivatives with tiny loading of Cu2O and 1H-imidazole-4-carboxylic acid as catalytic system under mild conditions, which provided good to excellent yields with good tolerance of functional groups. The 2nd Part: An efficient for a copper catalyzed domino coupling reaction has been developed,which afforded various oxindoles in good to excellent yields with tolerance of various substituents.