新型反應途徑合成類白葉藤鹼

A novel synthetic route to approach neocryptolepine

邱昱綸(Yu-Lun Ciou)

指導教授 ： 謝仁傑

淡江大學/理學院/化學學系碩士班/碩士(2016年)

https://doi.org/10.6846/TKU.2016.00246

摘要

第一部分:
以烏爾曼型態的反應方式合成出6H-吲哚[2,3-b]喹啉及其不同取代基的衍生物。
第二部分:
將第一部分的產物往後進行合成，並以總共四步驟的全合成得到類白葉藤鹼，為一種天然生物鹼，在醫藥方面上具相當的應用性。

關鍵字

夾竹桃科生物鹼 ； 類白葉藤鹼 ； 銅催化

並列摘要

The 1st Part :
We used Ullmann-type reaction to synthesize 6H-indolo[2,3-b] quinoline and its derivatives.

The 2nd Part :
We successfully synthesized Apocynaceae alkaloid, Neocryptolepine, in four steps. It has a wide spectrum of application in pharmacology.

並列關鍵字

neocryptolepine ； Apocynaceae alkaloid ； copper-catalyzed

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