This research of purpose is using Domain Driven Data Mining related technology discussion medical and the telecommunications two a industry case; discussion medical industry related data main to closed Closed-Loop Data Mining of technology, will academic related research and has clinical experience of professional physician do discussion of judgment, confirmed after of results will became to supporting physician for disease patients of situation developed treatment way of knowledge; also discussion telecommunications industry of related data except to Closed-Loop Data Mining of technology and combined Combined Mining based AKD framework, Reducing the gap in academic and commercial for commercial organizations to bring greater benefits.