In recent years, the Heart Rate Variability (HRV) has been a popularly studied subject. Among various non-invasive measurements of physiological signal, the HRV is an extensively utilized data to provide the most valuable physiological reference. The Zigbee technology is a rather mature technology it has the advantages of low cost, low power consumption and can be applied in long-time monitoring; it has many practical applications such as in the fields of security system, medication system and automation system. The task of this report is to apply HRV in the Zigbee-implemented wireless transmission system and to Integrate HRV and Zigbee together to change the current HRV transmission from the wired one into the wireless system. The characteristics of the wireless HRV signals will be investigated; it will study the possible transmission and coverage range of the integrated Zigbee-HRV wireless transmission system and try to remove the restriction of its transmission in the wired environment.