隅角閉鎖型青光眼於玻璃體之壓力分析

Pressure Distribution in an Eye Model of Angle-Closure Glaucoma

邱湘傑(Hsiang-Chieh Chiu)

指導教授 ： 李宗翰

共同指導教授 ： 黃曼菁

淡江大學/工學院/機械與機電工程學系碩士班/碩士(2009年)

https://doi.org/10.6846/TKU.2009.00961

摘要

青光眼，是僅次於白內障的致盲性眼疾。一般認為當眼壓過高使眼睛內部組織無法負荷，壓迫到視網膜組織，造成視神經的受損而導致失明。眼壓是由眼球內房水的生成與流出率所決定，當房水循環的過程中，因為阻塞，或是房水的生成、流出率失去平衡，都會使房水累積無法排出，造成眼壓升高。
本研究主要是在探討餘角閉鎖型青光眼於玻璃體外部所承受的壓力分佈狀況，以數值的方法分析眼球內壓力分布的情形。設計出一個包含前、後房以及水晶體及玻璃體的完整眼球模型，並且從房水生成、受阻、到對於玻璃體的擠壓，造成玻璃體外部的壓力分佈狀況，做出一套完整的模擬，借以觀察當房水受阻造成壓力時，對於視神經周圍細胞的影響。

關鍵字

房水 ； 眼壓 ； 青光眼 ； 視神經

並列摘要

Glaucoma is a leading cause of losing eyesight in the world, second only to cataract. In general, if intraocular pressure rose over the bearable limits of optical inner structure that lead to damage of the optic nerve, visual field loss, and ultimately sight loss. Intraocular pressure is mainly determined by the coupling of the production of aqueous humor and the drainage of aqueous humor mainly through the trabecular meshwork located in the anterior chamber angle. Any abnormalities of structure leads to unbalanced process and blockage, the intraocular pressure increased.
This study proposes a simulation mechanism of angle-closured glaucoma via elevating pressure applanated against vitreous body. To analyze the pressure of optical inner structure and design a model of complete eyeball including aqueous humor and vitreous body. This process is associated with increased intraocular pressure resulting from malfunction of aqueous drainage structures and malformation of vitreous body. Hence it damages the surrounding structures including optic nerves.

並列關鍵字

Angle-closured&nbspglaucoma ； Vitreous&nbspbody

參考文獻

3. L.A. Levin, “Models of neural injury”, Journal of Glaucoma, Vol. 10, pp. S19-S21, 2001

6. R.C. Tripathi, B.J. Tripathi, “Functional anatomy of the anterior chamber angle”, Biomedical Foundations of Ophthalmology Philadelphia, pp. 197, 1982

7. M .Johnson, and K .Erickson, “Mechanisms and routes of aqueous humor drainage”, Principles and Practice of Ophthalmology, Vol. 1, 2000

8. J. Heys, V. Barocas, and M. Taravella, “Modeling Passive Mechanical Interaction Between Aqueous Humor and Iris”, Journal of Biomechanical, Vol. 123, pp. 540-547, 2001

9. S. Kumar, S. Achara, R. Beuerman, and A. Palkama, “Numerical Solution of Ocular Fluid Dynamics in a Rabbit Eye: Parametric Effects”, Annals of Biomedical Engineering, Vol. 34, pp. 530-544, 2006