雙探針液晶感測器用於水中及斑馬魚體內之三價鐵離子檢測

Dual-probe liquid crystal sensor for specifically detecting ferric ion in water and zebrafish

廖育菱(Yui-Ling Laio)

指導教授 ： 陳志欣

淡江大學/理學院/化學學系碩士班/碩士(2022年)

https://doi.org/10.6846/TKU.2022.00754

摘要

在此研究中，我們合成具有螯合性質之兩親性質分子AZAC12，而後將10B2A與AZAC12兩種探針分子摻雜至液晶中，藉由雙分子探針的共同螯合作用來提升對於金屬離子之結合選擇性。當Fe3+與AZAC12和10B2A共同螯合後，分子因抓取金屬離子後改變了分子構型，因此擾亂了液晶排列，藉由暗-亮訊號的轉變可以得知水中是否有Fe3+存在，其偵測極限為50 M，且可以應用在自來水、飲用水中。此外，我們將摻雜雙探針的液晶滴液使斑馬魚吞食，觀察徑向液滴和雙極液滴之間的差異。由於液晶感測器操作簡便且訊號可以由肉眼辨識，此可攜式感測技術適合用於水中及生物體中的金屬離子快速篩檢。

關鍵字

液晶感測器 ； 兩親性分子探針 ； 三鐵離子檢測

並列摘要

In this work, we synthesized an amphiphilic molecule AZAC12, with chelating properties. Then the 10B2A and AZAC12 were doped into a nematic liquid crystal (LC) 5CB to construct the LC-based sensor with dual-probes for metal coordination. The coordination of Fe3+ with the aza-crown of AZAC12 and the carboxyl group of 10B2A disrupted the orientation of LCs, resulting in a dark-to-bright transition of LCs images. The lowest detectable concentration of this sensor for Fe3+ is 50 μM. This dual-probe LC sensor could be applied for Fe3+ detection in tap water, drinking water. On the other hand, we demonstrated that this system can be used to monitor the presence of Fe3+ in the intestines of zebrafishes. This dual-probe LC sensor is easy to operate and with visually recognizable signals, which make it suitable for rapid sensing of metal ions in water and living organisms.

並列關鍵字

Liquid crystal sensor ； Amphiphilic molecular probe ； Ferric ions detection

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