白花蛇舌草及半枝蓮對腫瘤抑制之文獻回顧

ARTICLE REVIEW OF ANTI-TUMOR EFFECT BY HEDYOTIS DIFFUSA AND SCUTELLARIA BARBATA

周楚瑩(Cho-Ieng Chao)

指導教授 ： 蔡女滿 ； 唐海誼

中山醫學大學/醫學科技學院/生物醫學科學學系碩士班/碩士(2018年)

摘要

中醫治療癌症中，中草藥常被使用於輔助降低癌症病人的化療和放療的副作用，以緩解患者的症狀。尋找有效的天然中草藥物來抑制腫瘤成為了當前腫瘤治療研究的焦點。隨著臨床上白花蛇舌草和半枝蓮常用於治療不同種類的腫瘤的中草藥，對其抑制腫瘤的活化成分及機制的研究越來越深入。白花蛇舌草來源為茜草科植物，乾燥全草入藥，其藥性微苦、甘寒，主要功用有清熱解毒、活血消腫、止痛抗菌和抗腫瘤等。白花蛇舌草中分離得到具有抗腫瘤活性的成分主要集中在三萜類、黃酮類、甾醇類、多醣體等成分。半枝蓮為唇形科黃芩屬植物的乾燥全草用藥，其藥性味辛、苦寒，具有清熱解毒、活血化瘀、消腫止痛和抗腫瘤等功效。黃酮類和多醣體是從半枝蓮分離得到具有抗腫瘤的活性成分。本文回顧總結近十年來白花蛇舌草及半枝蓮對腫瘤抑制的文獻，闡明二者含有黃酮、萜類、甾醇類和多醣體等抗腫瘤活性成分，其主要通過誘導腫瘤細胞凋亡、抑制腫瘤血管新生和增強機體免疫力等多種途徑引發抗腫瘤的作用，為臨床研究提供科學研究之理論依據，期許對臨床腫瘤患者提供更適當的腫瘤治療模式，更好地幫助腫瘤患者。

關鍵字

白花蛇舌草 ； 半枝蓮 ； 抗腫瘤

並列摘要

From the traditional Chinese medicine for treating cancer, the purpose of using Chinese medicine is to reduce the side effects of cancer chemotherapy and radiotherapy. Finding the effective natural herbal drugs to suppress tumors is the focus on research of current cancer therapy. In traditional Chinese medicine, the Hedyotis Diffusa and Scutellaria Barbata are the herb medicines and common used for treating different tumors. The recent studies of these two herbs have been report on active components and anti-tumor mechanisms. Hedyotis diffusa is derived from the dried whole plant of Rubiaceae family. It is used in traditional Chinese medicine for the treatment of heat-clearing, detoxification; the removal of blood stasis; antibacterial; anti-inflammatory and antitumor etc. Scutellaria barbata is a perennial herb of the Lamiaceae family, as a drying whole herb used in traditional Chinese medicine. It is used for heat-clearing; detoxification; promotion of blood circulation and antitumor etc. This article reviews the recent 10 years studies in the antitumor effect of Hedyotis Diffusa and Scutellaria Barbata. The studies indicate that two herbs contain of antitumor active ingredients, such as flavonoids, terpenoids, sterol and polysaccharides etc. Most of them play the antitumor effect through by inducing tumor cell apoptosis, inhibition of tumor angiogenesis and enhancing immune function. The aim of this review is to provide the theoretical evidence for the clinical research and application to help cancer patient’s well-being.

並列關鍵字

Hedyotis Diffusa ； Scutellaria Barbata ； Anti-tumor

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