大蒜水溶性含硫化合物對於糖尿病動物模式病情改善之效果

Anti-diabetic effect from 3 cysteine-containing compounds in diabetic mice

葉毓珊(Yu-Shan Yeh)

指導教授 ： 徐成金

中山醫學大學/健康管理學院/營養學研究所/碩士(2006年)

摘要

糖尿病併發症是造成糖尿病死亡的主要原因，尤其在心血管疾病方面。因此本研究探討在飲水中添加大蒜水溶性含硫化合物對於誘發糖尿病小鼠是否具有改善併發症的作用。使用BALB/c雄鼠經尾靜脈注射streptozotocin誘發糖尿病，然後飲水中分別添加1 g/L 的大蒜水溶性含硫化合物（SAC、SEC、SMC），分別為（1）Control組（2）DM-water組（3）DM-SAC組（4）DM-SEC組（5）DM-SMC組，飼養期間採取自由飲水的方式。結果顯示大蒜水溶性含硫化合物會使糖尿病小鼠之血糖、血脂與網狀纖維蛋白的濃度有顯著降低（p＜0.05）。飲用大蒜水溶性含硫化合物之糖尿病小鼠其纖維蛋白溶解系統中的纖維溶解蛋白酶原有明顯下降的現象（p＜0.05），而von Willebrand因子的活性也有下降之趨勢，在發炎反應中C反應蛋白濃度顯著下降（p＜0.05），飲用SAC及SEC的小鼠之IL-6有顯著性降低（p＜0.05）。由上述結果顯示，在飲水中添加大蒜水溶性含硫化合物，可減緩纖維化作用、凝血作用與發炎反應，這應有助於預防或緩和糖尿病併發症的發生。

關鍵字

糖尿病 ； 大蒜水溶性含硫化合物 ； 發炎反應

並列摘要

The protective effect from S-allyl cysteine (SAC), S-ethyl cysteine (SEC) and S-methyl cysteine(SMC) on diabetic mice against diabetic complications was studied. Diabetes was induced by streptozotocin treatment. These compounds were then added into drinking water. The results showed that the intake of these agents significantly reduced glucose, plasma triglyceride and fibronectin levels (p <0.05). These treatments also significantly decreased plasminogen level, c-reactive protein level (p<0.05) and von Willebrand factor activity. Both SAC and SEC treatments reduced IL-6 level (p<0.05). These data suggest that these compounds derived from garlic could alleviate inflammation, fibrosis and coagulation in diabetic mice, which might prevent the occurrence of diabetic complications.

並列關鍵字

diabetes ； cysteine-containing compound derived from garlic ； inflammation

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