探討腰臀比與糖尿病在不同 CYP1A2 rs762551 基因型的相關性研究

本研究目的為探討臺灣族群中CYP1A2基因rs762551單核苷酸多型性（CC/CA/AA）與腰臀比、喝咖啡習慣、喝茶習慣的第二型糖尿病風險。本研究為橫斷式研究，使用臺灣人體生物資料庫為資料來源進行研究分析，以邏輯斯回歸分析CYP1A2基因rs762551單核苷酸多型性（CC/CA/AA）、腰臀比、喝咖啡習慣、喝茶習慣的第二型糖尿病風險，調整相關干擾因子後，並進一步以腰臀比進行分層分析。本研究共有10,124位參與者進入研究分析階段，基因型CC有4316人、基因型CA有4615人，基因型AA有1193人。依基因型分組建立邏輯斯統計模型，依變項為第二型糖尿病，在Model 1（dominant model）分析中，基因型CC、CA+AA型的危險對比值分別為1.00（ref.）, 0.80（p=0.0368），喝咖啡習慣不顯著，喝茶習慣的危險對比值為1.50（p=0.0003），並且與腰臀比有交互作用（p=0.0025）。Model 2分析中，基因型CC、CA、AA的危險對比值分別為1.00（ref.）, 0.83（p=0.0957）, 0.69（p=0.0466），喝咖啡習慣不顯著，喝茶習慣的危險對比值為1.51（p=0.0003），並且與腰臀比有交互作用（p=0.0031）。進一步以腰臀比分層分析結果發現，和腰臀比正常組相比，腰臀比異常組得到第二型糖尿病的危險對比值分別為CA+AA型0.69（95%C.I.=0.55-0.87）、CA型0.72（95%C.I.=0.56-0.91）、AA型0.58（95%C.I.=0.38-0.87）。本研究結果顯示CYP1A2基因rs762551單核苷酸多型性（CC/CA/AA）與第二型糖尿病呈現負相關，此保護效果只在兩個變異的AA型中顯著。本研究進一步發現rs752551與腰臀比有交互作用，A變異能夠降低腰臀比異常組得到第二型糖尿病的風險，其關聯需要額外驗證。喝咖啡習慣在本研究的各個分析中皆不顯著。喝茶習慣則會增加第二型糖尿病的風險。

關鍵字

第二型糖尿病； CYP1A2基因； rs762551單核苷酸多型性；腰臀比；臺灣人體生物資料庫；喝咖啡習慣；喝茶習慣

並列摘要

The aim of this study was to investigate the association between type 2 diabetes and the CYP1A2 rs762551 single nucleotide polymorphism（CC/CA/AA）,waist-hip ratio, coffee consumption, and tea consumption in Taiwanese adults. The data were collected from the Taiwan Biobank. Logistic regression was used to determine the association between CYP1A2 rs762551 polymorphism（CC/CA/AA）and type 2 diabetes. The dominant and additive models were used and adjustments were made for confounders. A total of 10,124 adult enrollees were included in the final analysis. There were 4316, 4615, 1193 individuals with the CC, CA, and AA genotypes, respectively. There were 425 cases of type 2 diabetes. Using the dominant model（with the CC genotype as the reference）, the CA+AA genotype was significantly associated with a lower risk of type 2 diabetes. The odds ratio（OR）was 0.80; P=0.0368. No statistical significance was observed between coffee consumption and type 2 diabetes. However, tea consumption was significantly associated with a higher risk of type 2 diabetes（OR =1.50; P = 0.0003）. There was a significant interaction between the genotypes（CC and CA+AA）and waist-hip ratio（P = 0.0025）. Using the addictive model（with the CC genotype as the reference）, the CA genotype was not significantly associated with the risk of type 2 diabetes（OR=0.83; P=0.0957）. However, the AA genotype was significantly associated with a lower risk of type 2 diabetes（OR=0.69; P=0.0466）. Again, coffee consumption was not significantly associated with the risk of type 2 diabetes. However, tea consumption was significantly associated with a higher risk of type 2 diabetes（OR=1.51; P=0.003）. There was a significant interaction between the genotypes（CC, CA and AA） and waist-hip ratio（P=0.0031）. Further, the stratified analysis of waist-hip ratio showed that compared with the normal group, the risk of type 2 diabetes in the abnormal group was genotypes CA+AA 0.69（95%C.I.=0.55-0.87）, CA 0.72（95%C.I.=0.56-0.91）, AA 0.58（95%C.I.=0.38-0.87）. In conclusion, the rs752551 was associated with a lower risk of type 2 diabetes. However, a significant association was observed only in individuals with the AA genotype. In addition, significant interactions were observed between the rs752551 variants and waist-hip ratio. The A allele was associated with a lower risk of type 2 diabetes in individuals with an abnormal waist-hip ratio. Coffee consumption was not significantly associated with the risk of type 2 diabetes, while tea consumption was associated with a higher risk of type 2 diabetes. These findings require further investigations.

並列關鍵字

Type 2 diabetes ； CYP1A2 rs762551 polymorphism ； waist-hip ratio ； Taiwan Biobank ； coffee consumption ； tea consumption

參考文獻

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