木醣硫醇衍生物合成及其於奈米金之研究

Synthesis and characterization of thiolated xylose derivatives on gold nanoparticles

張家英(Chia-Ying, Chang)

指導教授 ： 張淑美

國立臺北科技大學/工程學院/有機高分子研究所/碩士(2012年)

摘要

本篇論文主旨為合成兩種木醣衍生物，其一為木醣接有親水性的乙二醇鏈，另一為木醣接有疏水性的長碳鏈，並在二者末端接上硫醇基，利用硫醇基將木醣衍生物修飾到金奈米粒子上。藉由量測穿透式電子顯微鏡與紫外/可見光光譜儀，可發現當金粒子表面修飾具疏水性的木醣衍生物時，粒子間會產生聚集的效果，而造成共振吸收峰的紅位移現象；當金粒子表面修飾具有親水性的木醣衍生物時，粒子會相當分散於溶液中，粒子與粒子不會有聚集現象，因而共振吸收峰並不會有明顯的差異。最後檢測生物毒性的結果為修飾有木醣衍生物的奈米金溶液不具毒性。

關鍵字

奈米金粒子 ； 表面電漿共振 ； 木類

並列摘要

The fast development of metal nanoparticles capped with organic monolayer is offering the possibility to create a whole new variety of products with novel characteristic, functions and applications. Among these, the nanoparticles covered with carbohydrates (glyconanoparticles) constitute a good bio-mimetic model of carbohydrate presentation at the cell surface and are currently centered on many glycobiologicle and biomedical applications. In this paper, a series of novel D-xylose gold nanoparticles with the linkers of alkyl or polyethylene glycol have been synthesized via D-xylosethiols formed self-assembled monolayers on gold nanoparticles. The xylose-modified gold nanoparticles characterize by using TEM, UV-Vis and colorimetry techniques and are investigated.

並列關鍵字

gold nanoparticles ； surface Plasmon resonance ； xylose

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