2-胺基丙二醇改質醚型聚胺酯/多壁奈米碳管複合材料之製備、鑑定和生物相容性

Synthesis , Characterization, and Biocompatibility of the Serinol-modified Polyurethane(Ether-typed)/Multi-walled Carbon Nanotube Composites

游雅琇(Ya-Hsiu Yu)

指導教授 ： 王賢達

國立臺北科技大學/工程學院/有機高分子研究所/碩士(2012年)

https://doi.org/10.6841/NTUT.2012.00063

摘要

本實驗以聚氧四亞基二醇(PTMO)和4,4’-二苯甲烷二異氰酸鹽(MDI)形成前驅物後，再以含保護基的2-胺基丙二醇(N-BOC-serinol)和1,4-丁二醇(1,4-butanediol)之混合溶液鏈延長合成改質PU，最後將其去活化接上氯醯化多壁奈米碳管形成改質聚胺基甲酸酯/多壁奈米碳管複合材料(MWNTs/PU)。

FTIR，NMR結果說明成功改質奈米碳管與改質PU的接枝。DSC與TGA結果顯示奈米碳管的添加，可提升材料的耐熱性。靜態接觸角測試數據顯示，奈米碳管添加量越高，MWNTs/PU親水性越佳。MWNTs/PU的表面電阻隨著奈米碳管添加量的增加降低。拉伸測試結果顯示，適量的加入奈米碳管可增強複合材之斷裂抗拉強度及楊氏模數，但斷裂延伸反而下降。

全血凝固動力試驗結果發現，相較於PU，全血在MWNTs/PU複材上較不易凝固，血液凝結測試也顯示加入適當量的MWNTs/PU的活化部份凝血質時間

(APTT)和凝血酶原時間(PT)是較長於PU，因此奈米碳管添加促成材料有較好的抗凝血特性。

關鍵字

聚胺酯 ； 改質聚胺酯奈米碳管 ； 複合材料 ； 生物相容性

並列摘要

Polytetramethylene oxide(PTMO) and 4,4’-diphenylmethane diisocyanide(MDI) with different molar ratios were used to synthesizing prepolymers. These products were chain-extended by N-BOC-serinol and 1,4-butanediol(BD) to form the modified polyurethane(PU). After the de-protection of BOC group of serinol, modified multi-walled carbon nanotubes (MWNTs) containing COCl groups were added to form chemically bonded composite (MWNTs/PU).

The chemical structures of intermediates and final products were confirmed by the FTIR and NMR methods. Decomposition temperature(5%wt loss) of MWNTs/PU was slightly higher than that of PU. Glass transition temperature and breaking tensile extension of MWNTs/PU were decreased upon increasing carbon nanotube loadings

in composites. Young’s modulus and surface electric resistivity were reduced by increasing carbon nanotubes content in MWNTs/PU.

Blood compatibility were tested with the whole blood clotting test and the blood coagulation methods. The results showed that the anticoagulation ability of MWNTs/PU was better than those of PU and the modified PU’s.

並列關鍵字

Polyurethane ； Multi-walled Carbon Nanotube ； Biocompatibility

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