可迴授之植入式高壓電刺激晶片

An Implantable High-Voltage Stimulator With a Voltage Feedback Loop

許劍星(Chien-Hsing Hsu)

指導教授 ： 邱弘瑋

國立臺北科技大學/電資學院/電腦與通訊研究所/碩士(2014年)

摘要

近年來生醫產業快速的發展，電刺激器的誕生更是醫學上嶄新的突破，而本論文所設計的電刺激器是以未來能夠植入人體中為目的，本論文利用無線傳電的技術，應用於植入式高壓電刺激晶片的開發，主要針對神經病變或損傷所產生的疼痛，給予神經脈衝射頻(Pulsed Radio-Frequency，PRF)電刺激治療，將神經病變損傷所產生的痛覺信號，暫時性的阻斷其傳導至大腦，達成止痛效果。
　　本論文主要著重於高電壓刺激晶片的研究，因為在低電壓的情況下，能給予電刺激的電壓電流大小有限，藉由高壓的方式，便能將電壓電流增大，給予更強的刺激效果。
　　實現方式上，整體系統利用電場耦合的方式來傳遞訊號，可分成發射端和接收的刺激晶片兩部分，發射端部份主要為Ｅ類功率放大器，接收晶片的部分為高壓電刺激晶片，高壓電刺激晶片在本論文中使用了兩種架構來分別實現，電路主要分為電源管理電路，訊號接收與回傳電路，PRF控制訊號產生電路，PRF產生電路，本論文中晶片皆採用TSMC 0.25UM CMOS製程來實現。
　　植入式晶片在生物相容性考量上，本論文也提出一個完整的植入式晶片封裝步驟，讓此植入式晶片能確實的去植入生物體內，增加可行性。

關鍵字

高壓 ； 電刺激 ； 晶片 ； 脈衝射頻 ； 止痛 ； 電場耦合

並列摘要

In recent year, biomedical and biological researches are vigorously growing.
The innovation of this stimulator is greatly considered a creative breakthrough in biomedical field.
In this thesis, our purpose is to implement a implanted HV stimulator. HV stimulator is utilizing a coupling coil to realize a power transmission wirelessly, and the stimulator use PRF(Pulsed Radio frequency) waveform with 500KHz carrier frequency to stimulate nerve to pain relief.
This thesis focuses on the HV stimulator researches, as in the case of low voltage stimulator will be limited of the voltage and current, by way of high-voltage, voltage and current can be increased, to give a stronger effect of stimulus .
On implementation, the overall system uses electric field coupling to deliver signals , it can be divided into transmitter and receiver, the main part of the transmitter power amplifier is the class-E PA, receiving part is the high-voltage stimulator chip, HV stimulator used in this thesis uses two kind different architecture to realize, and the circuit is divided into power management circuit, receive circuit and transmit circuit, PRF generating circuit, this thesis chips are using TSMC 0.25 UM CMOS process to achieve.
Implantable chip on the biocompatibility considerations, this thesis also proposes a complete implantable chip packaging steps to make this an implanted chip can implanted, increased viability.

並列關鍵字

high-voltage(HV) ； Stimulator ； chip ； PRF ； pain relief ； electric field coupling

參考文獻

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