- 學位論文
芳香基碘化物與膦酸乙烯基酯在可重複使用之鈀觸媒系統下於水相中進行Mizoroki-Heck反應與double Mizoroki-Heck反應
Reusable palladium-catalyzed Mizoroki-Heck reaction of aryl iodide with vinyl phosphonates in H2O
摘要
Mizoroki-Heck反應是目前形成碳-碳鍵中一種強而有效的方法，大部分都是使用對人體有害的有機溶劑作為反應介質，但就綠色化學的觀點來看，它對我們的環境是不利的。在我們的催化系統下，我們用水取代傳統的有機溶劑作為反應溶劑，我們將芳基碘化物與二乙烯基膦在非常低催化量的觸媒催化下進行Mizoroki-Heck反應，用二氯二氨鈀作為催化觸媒，DIPA作為鹼，水作為反應溶劑來進行Mizoroki-Heck反應可以得到高產率，另外，此反應可以在空氣下進行反應且不需要額外添加配位基，反應結束後鈀觸媒水溶液可以重複再使用於下一次的反應。
並列摘要
The Mizoroki-Heck reaction is one of the most powerful and effective methods to construct a C-C bond. Generally, harmful organic solvents were employed as the reaction medium, which is not environmentally-benign from the viewpoint of green chemistry. In our catalytic system, we use water as the reaction solvent instead of the conventional harmful organic solvents for the Mizoroki-Heck reaction of aryl iodides with diethyl vinyl phosphonates under very low catalytic loading. We use trans-dichlorodiammine palladium as the catalyst, diisopropylamine as the base, and water as the reaction medium to obtain the Mizoroki-Heck products in high yield. In addition, the reaction can be conducted under air and the addition of auxiliary ligand is not required. After reaction the residual aqueous solution can be reused for the next run.