This research develops a low cost water impedance vibration sensor. This sensor is composed of macromolecular compounds film, Copper foil, Cooper pillar, KNO3 and CH3COOH. The advantage of this sensor is to closely meet the skin. It is used to measure the vibration of radius artery. This research combines our sensor with DAQ card (Data Acquisition card) to develop a non-invasive measuring system. In time-domain, we can analyze the pulse to know the strength and frequency. In frequency-domain, we use FFT (Fast Fourier Transform) to find the first ten harmonic waves and estimate for the health according to the harmonic waves. This research measure the healthy people and the people who catch a cold, and discuss with the signal we measured.