生物醫學上的奈米粒子研究回顧

Review：nanoparticle researches in biomedicine

陳彥廷(Yen-Ting Chen)

指導教授 ： 侯劭毅

國立臺北科技大學/工程學院/生物科技研究所/碩士(2009年)

https://doi.org/10.6841/NTUT.2009.00114

摘要

奈米科學的發展對各種科學領域造成強烈的衝擊，使得各種不同的技術不斷被開發。在生物醫學方面，由於奈米粒子特殊的物理化學性質及生物相容性在偵測及診斷上成為常使用的平台。金奈米粒子可以和蛋白質（通常是抗體）以物理吸附或與經過硫醇修飾的核酸序列形成硫金共價鍵使其成為偵測探針。另外由於其特殊的光學特性（surface-enhanced Raman、Rayleigh scattering及aggregation dependent shifts in plasmon frequency）在生物醫學的診斷方面有很大的應用。奈米磁珠上也可以修飾抗體等蛋白質，利用抗原和抗體間的結合來捕捉特定蛋白。其最大特點在於能夠利用磁場使其純化蛋白。
在本篇文章中，主要著重在近幾年金奈米粒子（gold nanoparticle、nanorod及nanoshell）、奈米磁珠（magnetic nanoparticle）及其他奈米粒子用於生物醫學上的偵測、診斷及特殊應用。

關鍵字

金奈米粒子 ； 奈米磁珠 ； 偵測 ； 診斷

並列摘要

Advances in nanoscience have a significant impact on many scientific fields, boosting the development of a variety of important technologies. Because nanoparticles have special physicochemical properties and the biological compatibility, it become an important platform in the detection and the diagnosis. Gold nanoparticles bind with the proteins, such as antibodies, using physisorption or the sulfur-gold covalent bond to become the target-specific probe. In addition, because its special optics characteristic（surface-enhanced Raman、Rayleigh scattering and aggregation dependent shifts in plasmon frequency）,these are many applications in the biomedicine diagnosis aspect. The magnetic nanoparticle modified with antibody catches the specific protein using interaction force between the antigen and antibody. In this review, we examine recent advances in gold nanoparticles, magnetic nanoparticles and their application in biomedicine detection, diagnosis and other special applications.

並列關鍵字

gold nanoparticle ； magnetic nanoparticle ； detection ； diagnosis

參考文獻

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