利用幾丁聚醣包覆磁性磷酸鈣微粒做為肺癌熱治療的熱種子

Chitosan and Crossed Fe-DCPD Microparticles as Thermoseed for Lung Cancer Hyperthermia

胡景皓(Jing-Hao Hu)

指導教授 ： 唐自標 ； 林峯輝 ； 許淙慶

國立臺北科技大學/工程學院/材料科學與工程研究所/碩士(2012年)

https://doi.org/10.6841/NTUT.2012.00125

摘要

雙水磷酸氫鈣 ( CaHPO4•2H2O ) 為無毒性、可生物降解，且具良好生物相容性之材料。本研究希望藉由摻雜二價鐵離子 ( Fe2+ )，取代雙水磷酸氫鈣中鈣離子 ( Ca2+ ) 的晶格點位置，使材料具有磁性。將此材料做為熱種子置於癌細胞表面或內部，再施予外加交流磁場，即可利用磁滯損失的現象來產生熱，使溫度上升至43~46℃，便可殺死癌細胞。
在本研究中，為了使雙水磷酸氫鈣能延長在血液中停留的時間，和方便後續接枝動作，我們利用天然高分子幾丁聚醣 ( Chitosan ) 進行表面改質，利用幾丁聚醣在中性溶液中會凝結 ( gelation ) 的特性來包覆含鐵之磁性雙水磷酸氫鈣，最後在材料表面接枝上葉酸 ( Folic Acid )。葉酸可以使磁性的雙水磷酸氫鈣更有效率的標靶到癌細胞，期望將來有可以利用霧化吸入的方式應用於肺癌熱療上。

關鍵字

雙水磷酸氫鈣 ； 幾丁聚醣 ； 葉酸 ； 腫瘤熱治療 ； 磁滯損失 ； 霧化吸入

並列摘要

Dicalcium phosphate dehydrate ( DCPD ) is the major component of hard tissues like bone and teeth, which is non-toxic, biocompatibility and biodegradable. In this study, the Fe-DCPD particles was formed by co-precipitation method. The iron ions can substitute calcium ions of DCPD and form a magnetic DCPD；by doing this it can release heat in alternating magnetic field because it has magnetism. As temperature rise up to 43~46℃, the heat treatment will cause cancer cells dead.
However, in order to extend the blood circulation time and convenient graft, the surface modification is necessary. Surface modification use the natural polymer chitosan. Last in modify folic acid (FA) on the magnetic particle surface, improve the targeting rate. It is believed that magnetic Fe-DCPD/Chitosan-FA is one of the most potential materials in lung cancer hyperthermia by using in halation in the future.

並列關鍵字

DCPD ； Chitosan ； Folic acid ； Hyperthermia ； Hysteresis loss ； Inhalation

參考文獻

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