含氟氫氧基磷灰石沉積於G-II鈦金屬之研究

鈦金屬及合金因有良好的機械性質、抗腐蝕性與生物相容性常被用來作為骨科與牙科材料的應用。近幾年來，很多研究顯示氫氧基磷灰石披覆在生醫金屬表面上可以有效改善其生物相容性與生物活性，然而氫氧基磷灰石在生物環境下有較高的溶解速率，降低植入體與骨組織之間的形成鍵結。人體中骨骼與牙齒主要成分是氫氧基磷灰石，適量的氟離子能夠與氫氧基磷灰石作用形成含氟氫氧基磷灰石，增強刺激骨細胞反應與琺瑯質對酸的抵抗力。本研究先利用陽極處理在G-II鈦基材表面形成二氧化鈦奈米管作為中間層，並配置含鈣、磷、氟離子的電解液，並使用電化學沉積方法，以定電壓模式形成含氟的氫氧基磷灰石披覆在陽極處理後的鈦基材上，分析鍍層的相組成、元素組成、微結構與表面機械性質；並浸泡於人工體液中探討磷灰石的結構與表面形貌變化及抗腐蝕性。實驗結果顯示含氟氫氧基磷灰石鍍層有較大的表面粗糙度與表面硬度，浸泡於人工體液中表面會有磷酸鈣鹽類的析出，結晶性皆有隨著浸泡時間而逐漸增加趨勢。在動態極化試驗分析中，含氟氫氧基磷灰石鍍層可以改善在人工體液中的抗腐蝕性。

關鍵字

含氟氫氧基磷灰石；陽極處理；人工體液浸泡；腐蝕行為

並列摘要

Titanium and its alloy have been widely used as orthopedic and dental implants for few decades due to their good mechanical properties, corrosion resistance, and excellent biocompatibility. Recently, many in vitro researches reveal that the hydroxyapatite coatings on biomedical metal can improve biocompatibility and bioactivity. Nevertheless, the hydroxyapatite coating is easily decomposition and reduce the bonding between implants and bone tissue as a result of its high dissolution rate in biological environment. Hydroxyapatite is the inorganic component of bone and tooth. The medium amount of fluoride ion can substitute for OH− groups of the hydroxyapatite to form fluoridated hydroxyapatite which increases acid resistance and bone cell response. In this study, G-II Ti substrate is anodizated to form TiO2 nanotube. Fluoride ion is added into electrolyte which is composed of Ca and P ions, and then FHA coatings are prepared on anodized G-II Ti substrate at the constant voltage by electrochemical deposition. We will analyze the phase composition, elemental composition, microstructure and surface mechanical properties of the coating; and investigate changes of apatite structure, surface morphology and corrosion resistance in simulated body fluid. Results show that fluoridated hydroxyapatite coatings contain a large surface roughness and surface hardness. When immersed in simulated body fluid, the coatings will induce nucleation and growth of the apatite on the surface and increase the degree of their crystallinity. In Potentiodynamic polarization test, fluoridated hydroxyapatite coatings could improve the corrosion resistance in simulated body fluid.

並列關鍵字

Fluoridated hydroxyapatite ； Anodization treatment ； Simulated body fluid ； Corrosion behavior

參考文獻

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[2] Joyce Y. Wang and Joseph D. Bronzino, Biomaterials, Taylor & Francis Group,

[3] Mary Elizabeth Pecquet Goad and Dale L. Goad," Biomedical Materials and

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含氟氫氧基磷灰石沉積於G-II鈦金屬之研究

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