離子釋出在複合式骨替代材料性質之評估

Effects of Ion Dissolution on the Evaluation of Bone Substitute Composites

黃冠叡(Kuan-Ray Haung)

指導教授 ： 薛文景

國立臺北科技大學/工程學院/材料及資源工程系所/碩士(2006年)

摘要

磷酸鈣與硫酸鈣在骨替代材料使用上均具有相當良好的生物可吸收性與相容性，並各有其植入後的優缺點。本研究藉複合硫酸鈣與磷酸鈣來達成兩階段引導骨組織向內生長的目標。亦即控制不同鈣磷比之磷酸鈣與硫酸鈣複合而成新型骨替代材料，評估複合植入材料的基本性質，包括：硬化時間、機械性質、降解速率。所得複合材料再與氫氧基磷灰石(HA)添加至硫酸鈣而成的複合材料做比較。根據實驗結果得知不同磷酸鈣離子的釋出量會影響兩相間的界面接合，而這樣的差異會直接反映在機械性質與硬化時間上。浸泡實驗更顯示出僅添加氫氧基磷灰石之複合材並無離子釋出，所以沒有再結晶的現象發生，而新型複合骨材則因離子的釋出會在表面生成一層低結晶的缺鈣型磷灰石 (CDHA)，而此結晶層會阻隔水與硫酸鈣的接觸，以降低溶解速率。整體的實驗結果同時發現，含水量較低調和之新型複合骨替代材料可以有較高的機械強度及較趨緩的降解速率。

關鍵字

磷酸鈣 ； 硫酸鈣 ； 複合材

並列摘要

Having good bio-resorption and bio-compatibility, both calcium phosphate and calcium sulfate conceded their own advantage and disadvantage in the areas of human implantation. In this study, by controlling different Ca/P ratios, a novel composites material with bi-phase was investigated. The implant properties of this composites material including, setting time, mechanical property, and dissolution rate were compared with controlled substitute that mixed by calcium sulfate and hydroxyapatite (HA). Ionization occurring on the interfaces of calcium phosphate was observed to be the factor that resulted differences on the mechanical property of composites material and its setting time. A thin layer of CDHA crystalline was found on the surfaces of Ca/P controlled composites during the immersion tests. However, the crystallization was not occurred on the composites of which were hydroxyapatite added only. The formed layer was deduced to have a hydrophobic phenomenon. This could lead that the use of ion controlled composites in combination with lower ratio of liquid water might produce higher mechanical strength with delayed dissolution rate.

並列關鍵字

Calcium Phosphate ； Calcium Sulfate ； hydroxyapatite (HA) ； Composites ； dissolution rate.

參考文獻

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Patent 4612053, September 16 , 1986

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