Refrigeration system has a long history, and vacuum freeze-drying is a technology used for drying, color protection, fresh keeping, or nutrition preservation of food, biologics, biomaterials, or micro/nano materials, So Freeze-drying systems to be used for some time. But most operating temperature to the systems are -50℃, besides, old machines have only one cold trap chamber, if we want to remove the ice on cold trap, we will shutdown the machines, then Production process will be delayed. This thesis is focused on improving the cascade vacuum Freeze-drying Development, and this operating temperature can reach to -80℃,it is more favorable for specific high-tech products process and will not have a negative impact on production time. In experiments, freeze-drying system had a best evaporative temperature.