- 學位論文
關節液成份分子對聚醚醚酮生物材料摩擦行為的影響
The Effects of Synovial Fluid Compositions on the Tribological Behavior of PEEK Biomaterials
摘要
應用超高分子量聚乙烯與鈷鉻鉬合金組合是最常見的人工關節植入物，但是超高分子量聚乙烯的磨耗顆粒容易引發骨溶解反應(osteolysis)，導致人工關節鬆脫現象。在其他生物材料的發展上，有許多研究顯示，聚醚醚酮(PEEK) 複合材料已成功的應用在骨科和脊椎病人臨床表現，包含人工髖關節置換材料的植入物中。PEEK自身的性質在使用不同關節液分子模擬關節運動時的摩擦行為，以及關節液分子如何影響PEEK與CoCrMo合金的摩擦行為是值得研究探討。因此，本研究主要探討不同關節液成份分子在PEEK與CoCrMo合金材料中的摩擦行為影響。 本研究利用摩擦測試系統針對高分子材料聚醚醚酮(PEEK)以及鈷鉻鉬合金(CoCrMo)，在不同關節液分子白蛋白(albumin)、球蛋白（globulin）、玻尿酸(hyaluronic acid)、磷脂質(lipid) 以及玻尿酸混合其他關節液成份進行摩擦測試試驗，探討各成分濃度對於PEEK與CoCrMo合金摩擦的影響。從實驗結果發現，單成分關節液中玻尿酸的摩擦係數相對於其他關節液分子是最低的，推斷是玻尿酸溶液的黏彈性在邊界潤滑中增加了關節液的黏度和提高流體薄膜的厚度，降低在整體摩擦系統中的摩擦係數。在雙成分關節液分子的測試中顯示，玻尿酸的加入，使得白蛋白、球蛋白、磷脂質的混合關節液摩擦係數均較其單成分低。推斷是玻尿酸本身的黏性性質能鎖住部分關節液分子，造成其他關節液分子較不易吸附在對磨材料表面，在摩擦過程中達到動態平衡，無法完全增加其摩擦力，加上玻尿酸分子的彈性性質提高流體薄膜的厚度，降低部分的摩擦力，使得所測的系統摩擦係數較單成分關節液低。
並列摘要
Application of ultra-high molecular weight polyethylene and CoCrMo alloy composition is the most common artificial joint implants, but the amount of ultra-high molecular weight polyethylene worn granules dissolved easily lead to bone response (osteolysis), followed with loosening of artificial joint phenomenon. In the development of other biological materials, many studies have shown polyether ether ketone (PEEK) composite materials have been successfully used in clinical orthopedic and spine patients, including total hip replacement implants in the material. It’s worth studying what PEEK itself property under different joint synovial element simulating the friction behavior duing joint movement, and surveying how joint synovial elements affect the friction behavior on PEEK/CoCrmo alloy. Therefore, this study is aimed to investigate the synovial fluid composition of different elements in PEEK and CoCrMo alloy material in the friction behaviors. In this study, the related friction test system will include polyetheretherketone (PEEK) and cobalt-chromium molybdenum alloy (CoCrMo)at different synovial fluid elements albumin, globulin, hyaluronic acid and phospholipids (lipid) and synovial fluid hyaluronic acid mixed with other ingredients for friction tests to the concentration of each component of PEEK and CoCrMo alloys for the effects of friction. From the experimental results, single-ingredient hyaluronic acid in synovial fluid friction coefficient relative to other synovial fluid molecules is the lowest, thanks to inference is viscos-elastic of hyaluronic acid solution in the boundary lubrication increased the viscosity of synovial fluid and improve the fluid film thickness, to reduce overall friction coefficient of friction system. Synovial fluid in the two-component molecular test shows that the addition of hyaluronic acid, making of albumin, globulin, phospholipids to formulate into synovial fluid friction coefficient is lower than its single components. Inference is the hyaluronic acid itself viscous properties of synovial fluid elements can be party limited, causing other joint fluid elements more difficult to be adhered onto the surface, to achieve a dynamic equilibrium in the friction process, not to increase the friction. The elastic properties to hyaluronic acid will result in increasing the thickness of fluid film which decreases the system friction. The final result shows the friction coefficient of two-compound is lower than single component joint fluid.